抗β2-糖蛋白I抗体和复发性流产的关系  

Study on the relation between anti β2-glycoprotein I antibodies and recurrent abortion

作　　者：张红媛[1] 王谢桐[1] 

机构地区：[1]山东大学附属省立医院妇产科,济南250021

出　　处：《中华产科急救电子杂志》2014年第2期46-49,共4页Chinese Journal of Obstetric Emergency（Electronic Edition）

摘　　要：目的探讨抗β2-糖蛋白I抗体和复发性流产的关系。方法收集2012年1月1日至12月31日就诊于山东大学附属山东省立医院的210名抗心磷脂抗体阴性的复发性流产患者和80例正常经产妇的临床资料，检测其血清中的抗β2-糖蛋白I抗体水平，并分析复发性流产患者接受抗凝治疗的效果，以及探讨该类患者接受抗凝治疗的抗β2-糖蛋白I抗体水平。结果（1）复发性流产患者抗β2-糖蛋白I抗体主要与IgM抗体相关，本研究中210例复发性流产患者抗β2-糖蛋白I抗体IgM阳性人数为48例，发生率为22．9％。（2）对于抗β2-糖蛋白I抗体IgM为15—20RU／ml的复发性流产患者，采取抗凝治疗的妊娠成功率（66．7％，14／21）明显高于未接受抗凝治疗者（19．4％，6／31），差异有统计学意义（x^2=11．840，P〈0．05）。（3）对于抗β2-糖蛋白I抗体IgM≥15RU／ml的复发性流产患者，采取抗凝治疗的妊娠成功率（70．6％，36／100）明显高于未接受抗凝治疗者（18．4％，9／49），差异有统计学意义（x^2=27．535，P〈0．05）。结论抗β2-糖蛋白I抗体IgM和复发性流产有相关性，当抗β2-糖蛋白I抗体IgM≥15RU／ml即可采取抗凝治疗。Objective To explore the relation between anti β2-glycoprotein I antibodies and recurrent abortion. Methods This study collected the clinical data of 210 recurrent abortion patients with anticardiolipin antibody negative and 80 normal muhiparas, who were admitted in the Shandong Provincial Hospital Affiliated to Shandong University from January 1st to December 31^st 2012. To explored the level of anti β2-glycoprotein I antibody immunoglobulin M （IgM） for treating the recurrent abortion, serum anti β2-glycoprotein I antibodies of the patients were collected and anticoagulant therapy effects of the recurrent abortion patients were analyzed. Results （1） The recurrent abortion patients were related with anti β2-glycoprotein I antibody IgM. Among the 210 recurrent abortion patients, 48 patients were anti β2-glyeoprotein I antibody IgM positive; the incidence rate was 22. 9%. （2） For the recurrent abortion patients with 15-20 RU/ml anti β2-glycoprotein I antibody IgM, the successful pregnancy rate in anticoagulant therapy group （66. 7%, 14/21 ） were significantly higher than that in control group （ 19.4% ,6/31 ）, （ x^2 = 11. 840, P value 〈0. 05）. （3） For the recurrent abortion patients with equal or more than 15 RU/ml anti β2-glycoprotein I antibody IgM, the successful pregnancy rate in anticoagulant therapy group （70. 6%, 36/100） were significantly higher than that in control group （18.4% ,9/49）, （ x^2 = 27. 535, P value 〈 0. 05 ）. Conclusions There was relation between recurrent abortion patients and anti β2-glycoprotein I antibody IgM. When anti β2-glycoprotein I antibody IgM was equal or more than 15 RU/ml, the recurrent abortion patients should be treated with anticoagulant therapy.

关 键 词：流产 习惯性 抗Β2-糖蛋白I抗体 治疗 

分 类 号：R714.21[医药卫生—妇产科学]