真实世界中过敏性紫癜的发病特点及中医证候分布  

Study on Pathogenic Characteristic and Syndrome Distribution of Allergic Purpura in Real World

作　　者：燕丽[1,2] 王连心[1] 谢雁鸣[1] 杨薇[1] 孙勇[3] 庄严[4] 王永炎[1] 

机构地区：[1]中国中医科学院中医临床基础医学研究所 [2]首都医科大学附属北京儿童医院 [3]中国人民大学 [4]中国人民解放军海军总医院

出　　处：《中医杂志》2014年第21期1872-1876,共5页Journal of Traditional Chinese Medicine

基　　金：国家"重大新药创制"科技重大专项资助项目(2009ZX09502-030)

摘　　要：目的探讨真实世界中过敏性紫癜患者的发病和年龄、性别、节气的关系及其中医证候分布特点。方法采集2008年1月至2010年12月全国19家三级甲等医院2110例过敏性紫癜住院患者信息,对患者西医诊断、中医诊断、中医证候信息进行规范化后,提取患者一般信息及中医证候信息进行频次统计,并绘制雷达图对患者发病情况与节气的关系进行关联分析。结果 2110例过敏性紫癜患者中性别记录缺失145例,男性1122例,女性843例;有年龄记录者1327例,年龄分布以18岁及以下患者为主,共886例（66.77%）,其他依次为19~44岁294例（22.15%）,45~59岁76例（5.73%）,60~74岁57例（4.30%）,75~89岁14例（1.05%）。有出院主证记录的172例患者中医证候主要为血热妄行107例（62.20%）,其他依次是气不摄血36例（20.93%）、风热伤络15例（8.73%）。雷达图显示,寒露、霜降、立冬、小雪、大雪、冬至、小寒及清明过敏性紫癜发病率明显高于其他节气。结论过敏性紫癜患者以儿童为主,男性患者相对较多,春季和秋冬季为该病高发季节,其中医证候主要为血热妄行。Objective To discuss the relations between the onset of allergic purpura and patient＇s age, gender and solar term, and to observe the distribution characteristic of TCM syndrome. Methods The information of 2 110 allergic purpura inpatients in 19 hospitals nationwide was collected from January 2008 to December 2010. The information of western medicine diagnosis, TCM diagnosis and TCM syndrome was normalized. The general and TCM syndrome information was extracted for frequency statistics and a radar map was created to analyze the correlation be- tween disease onset and solar terms. Results Among 2110 allergic purpura patients, 1 122 were male （57.10%） and 843 were female （42. 90% ）, 145 cases gender records missing. Cases with clear age records were 1 327, including 886 cases （66. 77% ） aged 18 years old or＇under, 294 cases （22. 15% ） aged from 19 years old to 44 years old, 76 cases （5.73%） aged from 45 years old to 59 years old, 57 cases （4. 30% ） aged from 60 years old to 74 years old and 14 cases （1.05%） aged from 75 years old to 89 years old. Among 172 patients with discharge symptom records, the main TCM syndrome was frenetic movement of hot blood （ 107 cases, 62.20% ） and foffowed by qi failing to control blood （36 cases, 20. 93% ） and wind-heat invading the collateral （ 15 cases, 8.73% ）. The morbidity of allergic purpura in Cold Dew, Frost＇s Descent, Winter Commences, Light Snow, Heavy Snow, Winter Solstice, Slight Cold and Tomb-Sweeping Day was significantly higher than that in other solar terms. Conclusion Most of allergic purpura patients are children. The percentage of male patients is relatively high. Spring, summer and winter are the high-occurrence seasons. The main TCM syndrome is bleeding due to blood-heat.

关 键 词：过敏性紫癜 证候分布 医院信息管理系统 真实世界研究 

分 类 号：R259[医药卫生—中西医结合]