养血祛风方对抽动障碍大鼠学习记忆能力的影响  

Effects of Blood Nourishing and Wind Expel Formulae on Learning and Memory Capabilities of Rats with Tic Disorders

作　　者：吴力群[1] 魏丽娜[1] 尹英敏[1] 陈海鹏[1] 

机构地区：[1]北京中医药大学东方医院,北京100078

出　　处：《中国中医药信息杂志》2014年第11期72-74,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：北京市自然科学基金(7122096)

摘　　要：目的探讨养血祛风方对大鼠空间学习记忆能力的改善作用。方法采用亚氨基二丙腈腹腔注射制造抽动障碍大鼠模型,将造模成功的大鼠随机分为模型组、西药组及中药低、中、高剂量组,各给药组给予相应药物灌胃,正常组和模型组给予等量生理盐水灌胃,连续8周。造模后第1、4、8周分别进行旷场分析及水迷宫实验,评价各组大鼠空间学习记忆能力。结果与正常组比较,模型组跨格次数增加,垂直活动次数明显减少;与模型组比较,各给药组垂直活动次数增加;第4、8周中药中、高剂量组模型大鼠逃避潜伏期明显缩短(P<0.05)。结论养血祛风方中、高剂量有改善慢性抽动障碍大鼠学习记忆能力的作用。Objective To observe the effects of blood nourishing and wind expel formulae on learning and memory capabilities of rats with tic disorders. Methods Intradialytic Parenteral Nutrition peritoneal injection was used to establish the rat model of tic disorders. The successful test subjects were categorized into 5 different groups, namely the model group, the Chinese medicine groups （low dosage, medium dosage and high dosage） and the western medicine group. The test groups were each given gastric perfusion of the related medicine, whereas the control and model groups were each given equal amounts of saline solution continuously for 8 weeks. Open field test and water maze test were carried out in the 1st, 4th and 8th weeks to evalute the learning and memory capabilities. Results In comparison with the control group, the model group showed obvious increase in movement across grid and decrease in vertical locomotion. Statistical significance was obtained showing an increase in vertical locomotion in the treatment groups compared with the model group. In the Chinese medicine groups, the medium and high dosage groups exhibited shorter escape latency and increased exploratory behavior （P〈0.05） in the 4th and 8th weeks. Conclusion Among the blood nourishing and wind expel formula, the medium and high dosage showed ameliorating effects on the memory and learning capabilities of rats with tic disorders.

关 键 词：养血祛风方 抽动障碍 学习记忆能力 大鼠 

分 类 号：R285.5[医药卫生—中药学]