自身抗体与狼疮肾炎病理类型的相关性分析  

A Correlational Analysis of Autoantibodies and Lupus Nephritis Pathological Types

作　　者：严艳玲 袁林 杨明辉[3] 刘云峰 向诗飞 张翠兰[4] 向阳 袁国华[2,3] 

机构地区：[1]开县人民医院,重庆开县400500 [2]风湿性疾病发生与干预湖北重点实验室,湖北恩施445000 [3]川北医学院附属医院风湿免疫研究所,四川南充637000 [4]湖北民族学院附属民大医院风湿免疫科,湖北恩施445000

出　　处：《湖北民族学院学报（医学版）》2014年第3期12-14,18,共4页Journal of Hubei Minzu University(Medical Edition)

摘　　要：目的 探讨自身抗体与狼疮肾炎（lupus nephritis,LN）病理类型的相关性.方法 采用免疫印迹法测定75例行肾活检LN患者的抗dsDNA、抗Sm、抗SSA、抗U1nRNP、抗核小体（NUC）及抗组蛋白（HIS）抗体,并与56例无肾脏损害的系统性红斑狼疮（systemic lupus erythematosus,SLE）患者对照,分析自身抗体与LN病理类型的关系.结果 75例LN患者中,抗dsDNA、抗Sm和抗HIS阳性率均明显高于无肾脏损害患者（P＜0.05）;75例LN病理类型分属Ⅰ～Ⅵ型,与无肾脏损害组对照,抗dsDNA和抗HIS抗体阳性率在各型LN中均增高,但仅Ⅱ型LN差异有统计学意义（P＜0.01）,抗SSA抗体在Ⅰ型LN中与无肾脏损害组对照,差异有统计学意义（P＜0.05）,抗U1nRNP抗体在Ⅴ型LN中与无肾脏损害组对照,差异有统计学意义.结论 抗dsDNA抗体、抗Sm抗体和抗HIS抗体阳性可指导LN的诊断,且抗dsDNA抗体和抗HIS抗体与Ⅱ型LN发病相关,抗SSA抗体与Ⅰ型LN发病有关,抗U1nRNP抗体则可能在Ⅴ型LN病变中发挥作用.Objective To analyze the association between anti-extractable nucler antigen （ENA） and the histological changes in luPus nephritis（LN） .Methods The anti-dsDNA,anti-SSAI,anti- U 1 nRN P/Sm, anti-nucleosome （ N UC）, and anti-histone antibody were detected in 75 patients with LN underwent renal biopsy and 56 patients without LN by using Western-blot assay,followed by analyzeing the relations between the anti-ENA autoantibodies and LN pathological changes.Results In 75 patients with LN,anti-dsDNA antibodies, Sm and anti-histones （HIS） antibodies positive rate were significantly higher than those of patients without kidney damage （P〈0.01） ;75 cases of LN pathological type belong to Ⅰ -Ⅵ type,compared with no kidney damage control group,anti-dsDNA antibodies and protein antibody positive rate in each model LN resistance group were increased,but only type Ⅱ LN difference was statistically significant （P〈0.01）,and anti-SSA antibody in type Ⅰ LN compared with no kidney damage control group,the difference was statistically significant （P〈0.05）.Conclusion Anti-dsDNA antibodies, anti-Sm and anti-histones antibody positive can guide the diagnosis of LN ,and dsDNA antibodies associated with the onset of type Ⅱ LN,anti-SSA antibody associated with the onset of type Ⅰ LN,and anti-U1nRNP antibodies may play a role in the type V LN pathological changes.

关 键 词：系统性红斑狼疮 狼疮肾炎 自身抗体 相关性 分析 

分 类 号：R593.242[医药卫生—内科学]