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作 者:肖文[1] 薛海龙[1] 贾秀丽[1] 何志义[2]
机构地区:[1]解放军第三医院神经内科,陕西省宝鸡市721004 [2]中国医科大学附属第一医院神经内科
出 处:《中国医药》2014年第11期1596-1598,共3页China Medicine
基 金:国家自然科学基金(81070913)
摘 要:目的 探讨脑卒中相关性肺炎(SAP)对脑梗死患者病情及预后的影响.方法 选取97例SAP患者为SAP组和选取同期在本院治疗的未发生SAP的脑梗死患者100例为对照组,探讨分析脑卒中的相关影响因素,并比较2组患者的实验室检查指标、生存预后情况.结果 SAP组多发部位梗死率为26.8%(26/97),C反应蛋白为(116±70) mg/L,红细胞沉降率为(23±14)mm/1 h,均明显高于对照组[多发部位梗死率为6.0% (6/100),C反应蛋白为(75 ±41)mg/L,红细胞沉降率为(10 ±5)mm/1 h],差异均有统计学意义(均P<0.05).SAP组患者入院时NIHSS评分、APACHEⅡ评分高于对照组,差异均有统计学意义[(16±5)分比(9±4)分,t=10.90;(17±5)分比(7±4)分,=6.88,均P<0.01].SAP组C反应蛋白、红细胞沉降率均明显高于对照组[(116±70) mg/L比(75 ±41)mg/L,(23±14)mm/1 h比(10±5)mm/1 h],前清蛋白、清蛋白均明显低于对照组,差异均有统计学意义[0.25(0.11,1.03) g/L比0.36 (0.19,1.00) g/L,(30±5)g/L比(35 ±3)g/L,P<0.05或P<0.01];采用单因素Logistic回归分析SAP的影响因素发现:多发部位脑梗死、NIHSS≥15分、APACHEⅡ≥20分为SAP的危险因素,比值比(95%置信区间)分别为5.737(2.242 ~16.682)、13.588(6.527 ~28.290)、7.329(2.688 ~19.980),差异有统计学意义(P<0.05),上述因素可以使脑卒中患者发生SAP的危险增加4.596 ~13.588倍.结论 SAP对患者的病情、生存预后影响较大,应及时采取措施预防SAP的发生,以改善脑梗死患者的生存预后、生活质量,降低病死率.Objective To investigate the effects of stroke-associated pneumonia(SAP) on the severity and the prognosis of patients with cerebral infarction.Methods Ninety-seven patients with stroke-associated pneumonia(SAP group) and 100 cases(control group) with only stroke patients were selected to investigate factors affecting stroke.The laboratory parameters and survival rate were compared.Results For the group SAP,multiple sites infarction rate was 26.8% (26/97),C-reactive protein(CRP) was (116 ± 70) mg/L ; erythrocyte sedimentation rate(ESR) was (23 ± 14) mm/1 h.All of the three were significantly higher than those of the control group [(multiple sites infarction rate was 6.0% (6/100),C-reactive protein was (75 ±41)mg/L,erythrocyte sedimentation rate was (10 ± 5) mm/l h] (P 〈 0.05).Multiple sites infarction,NIHSS ≥ 15 points,APACHE Ⅱ ≥ 20 were SAP's risk factors [5.737 (2.242-16.682),13.588 (6.527-28.290),7.329 (2.688-19.98),all P 〈0.05] ; CRP and ESR of SAP patients were significantly higher [(116 ± 70) mg/L vs (75 ± 41) mg/L,(23 ±14) mm/1 h vs (10 ± 5) mm/1 h] but PAB and ALB were significantly lower [0.25 (0.11,1.03) g/L vs 0.36 (0.19,1.00)g/L,(30 ±5)g/L vs (35 ±3)g/L,P 〈0.05 or P 〈0.01] than those of the control group (P 〈0.05) ;the survival prognosis of SAP patients was worse than that in the control group (P 〈 0.05).Conclusions SAP can produce great impact on the patient's condition and the prognosis of survival.Measures to prevent the occurrence of SAP should be taken timely to improve the patient's condition and the prognosis of survival.
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