高敏C反应蛋白与颈动脉粥样硬化的相关性研究  

Relation between high sensitivity C-reactive protein and carotid atherosclerosis

作　　者：张军伟[1] 王宝华[1] 杨颖[1] 白静[1] 程爱斌[1] 

机构地区：[1]河北联合大学附属医院重症医学科,河北省唐山市063000

出　　处：《中国医药》2014年第11期1613-1615,共3页China Medicine

摘　　要：目的 探讨高敏C反应蛋白（hs-CRP）和颈动脉粥样硬化的关系.方法 选取唐山市某社区年龄在25～90岁的161例志愿者为研究对象,根据其血浆hs-CRP水平分为高hs-CRP组（hs-CRP＞3mg/L,80例）和hs-CRP正常组（hs-CRP≤3 mg/L,81例）,经颈部血管超声检查,观察2组受检者颈动脉内膜-中层厚度、颈动脉斑块性质及管腔狭窄程度.结果 高hs-CRP组受试者的平均年龄大于hs-CRP正常组,差异有统计学意义[（60±13）岁比（48±7）岁,t=-7.81,P＜0.01].高hs-CRP组颈总动脉和颈内动脉内膜中层厚度均大于hs-CRP正常组,差异均有统计学意义[分别为（0.86 ±0.16）mm比（0.76 ±0.12）mm,t＝-4.390,P＜0.01;（0.74±0.11）mm比（0.68 ±0.06） mm,t=-3.560,P＜0.01].高hs-CRP组斑块检出率为93.8％ （75/80）,高于hs-CRP正常组的34.6％（28/81）（χ2 =35.96,P＜0.01）.颈总动脉和颈内动脉狭窄的检出率在高hs-CRP组为45.0％（36/80）和17.5％（14/81）,高于hs-CRP正常组[分别为18.6％（15/81）、3.7％（3/81）],差异有统计学意义（χ2=12.70,P＜0.01;χ2=8.11,P＜0.01）.结论 高水平的hs-CRP促进正常人群的动脉粥样硬化.Objective To study the correlation between serum high sensitivity C-reactive protein （hs-CRP）and carotid atherosclerosis.Methods Totally 161 volunteers from 25 to 90 years old were collected.The serum level of hs-CRP was measured and separated into high hs-CRP group and hs-CRP normal group.The carotid atherosclerosis was detected by the color Doppler ultrasound to check intima-media thickness （IMT）,followed by measurements for the state of carotid artery atherosclerosis and the rate of vessel stenosis.Results The average age in high hs-CRP group was higher than that of the hs-CRP normal group,which showed a significant difference [（60 ± 13） years vs.（48 ± 7） years,t =-7.81,P 〈 0.01].The common carotid artery IMT,internal carotid artery IMT and carotid artery plaque for the high hs-CRP group were （0.86 ± 0.16） mm,（0.74 ± 0.11） mm,and 93.8% （75/80） respectively,while they were（0.76 ±0.12） mm,（0.68 ± 0.06） mm and 34.6% （28/80） in hs-CRP normal group,which demonstrates significant differences between the two groups（t =-4.39,P 〈0.01 ;t =-3.56,P 〈 0.01 ;χ2 =35.96,P 〈 0.01）.Compared to the hs-CRP normal group [18.6% （15/81）,3.7% （3/81）],the detection rate of stenosis of the common carotid artery and internal carotid artery in high hs-CRP group was 45.0% and 17.5%,which showed a significant difference （χ2 =12.70,P 〈0.01 ;χ2 =8.11,P 〈0.01）.Conclusion High level of hs-CRP can enhance carotid atherosclerosis.

关 键 词：高敏C反应蛋白 动脉粥样硬化 彩色多普勒超声 

分 类 号：R543.4[医药卫生—心血管疾病]