焦炉工人尿1-羟基芘与肺通气功能损伤的关系  

Relationship between pulmonary ventilation function damage and urinary 1-hydroxypyrene in coke-oven workers

作　　者：张红明[1] 智永芬 李克贤[1] 李卫星[2] 胡志鹏[2] 刘卫花[2] 李扬帆[2] 郑金平[2] 

机构地区：[1]山西焦化集团有限公司职业病防治所,山西洪洞041606 [2]山西医科大学公共卫生学院卫生毒理学教研室

出　　处：《环境与健康杂志》2014年第7期595-597,共3页Journal of Environment and Health

基　　金：国家自然科学基金(30872137);山西省自然科学基金(2009011049-1);山西省优势和特色重点学科建设经费;山西医科大学科技创新基金(01200701)

摘　　要：目的研究焦炉工人尿1-羟基芘(1-OHP)及其蓄积作用与肺通气功能损伤的关系。方法于2009年6—7月选取某焦化厂185名焦炉作业工人为暴露组,同厂辅助工种145人为对照组。使用统一的调查表收集个人基本信息,采用高效液相色谱法检测作业环境空气中苯并(a)芘和研究对象尿1-OHP浓度,采用肺功能仪测定肺功能指标。结果暴露组工人25%肺活量时呼气流速(FEF25)、肺活量(VC)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)均低于对照组,差异有统计学意义(P<0.05)。以尿1-OHP浓度2.3μmol/molCr为界值将暴露组分为高暴露和低暴露,高暴露组75%肺活量时呼气流速(FEF75)、FEF25、VC、FVC、FEV1均低于低暴露组,差异有统计学意义(P<0.05)。多重线性逐步回归分析结果显示,暴露组尿1-OHP浓度与50%肺活量时呼气流速(FEF50)、FEF25、最大呼气流速(PEF)、VC、MVV、FEV1呈负相关(P<0.05),尿1-OHP的蓄积作用与VC、FVC、MVV、FEV1呈负相关(P<0.05)。结论焦炉工人尿1-OHP及其蓄积作用与肺功能损伤有关,可用来反映焦炉工人肺功能损伤情况。Objective To understand the relationship between urinary 1-hydroxypyrene （1-OHP） concentrations and lung function injury in coke-oven workers. Methods A total of 185 coke-oven workers were selected as the exposure groups and 145 unexposed workers were selected as the control group. The general information was collected through uniform questionnaire. 1-OHP in urine was measured by HPLC. Lung function indicators were determined by using portable spirometer. Results FEF25, VC, FVC, and FEV1 in the coke-oven group were significantly lower compared with those of control group. The exposed workers were divided into high and low exposure groups based on 2.3 μmol/mol Cr of 1-OHP, and FEF75, FEF25, VC, FVC and FEV1 in the high exposure group were significantly lower than those in the low exposure group. In the coke-oven group, the level of urinary 1-OHP was negatively correlated with FEF50, FEF25, PEF, VC, MVV and FEV1 （P〈0.05）. The urinary accumulation of 1-OHP was negatively correlated with VC, FVC, MVV and FEV1. Conclusion The urinary 1-OHP level and the accumulation of 1-OHP can be used to detect the early lung function injury in coke-oven workers.

关 键 词：焦炉工人 焦炉逸散物 尿1-羟基芘 蓄积作用 肺功能 

分 类 号：R181.3[医药卫生—流行病学]