长期服用银杏叶片治疗突发性耳聋的远期疗效观察  

Long-term efficacy of long-term use of ginkgo biloba extract in the treatment of sudden deafness

作　　者：杨彰斌[1] 洪海裕[2] 郭剑玲[2] 陈源[2] 

机构地区：[1]中山大学附属第五医院中医科,广东珠海519000 [2]中山大学附属第五医院耳鼻咽喉科,广东珠海519000

出　　处：《海南医学》2014年第20期2999-3001,共3页Hainan Medical Journal

基　　金：珠海市科技局基金(编号:2012D0401990021)

摘　　要：目的观察长期服用银杏叶片治疗突发性耳聋的临床效果。方法将60例突发性耳聋患者随机分为对照组和治疗组,每组30例。两组患者均接受口服泼尼松加前列地尔静脉滴注等常规治疗14 d;治疗组在常规治疗基础上加用口服银杏叶片治疗1年,一次1片,3次/d。分别于开始治疗、治疗第14天、治疗第3个月及治疗后1年评估相关症状及复查电测听。结果治疗第14天两组患者无论听力或者耳鸣等症状,组间差异均无统计学意义(P>0.05);治疗后3个月及治疗后1年听力疗效方面,治疗组有效率分别为76.7%(23/30)及83.3%(25/30);对照组有效率分别为50.0%(15/30)及60.0%(18/30),差异均有统计学意义(P<0.05)。治疗后1年,35例伴发耳鸣者,治疗组耳鸣改善率为66.7%(12/18),对照组改善率为29.4%(5/17),差异有统计学意义(P<0.05)。结论长期口服银杏叶片治疗突发性耳聋方法简便,具有确切的远期疗效,用药安全,值得临床推广。Objective To observe the long-term effect of the treatment for sudden deafness with long-term use of ginkgo biloba extract. Methods Sixty patients of sudden deafness were divided into the control group （30 cas-es） and the treatment group （30 cases） in random. The two groups were all given prednisone and alprostadil by intrave-nous infusion simultaneously, and the treatment group was given one-year use of ginkgo biloba extract additionally, one piece per time, 3 times per day. Audiometry and symptoms were tested and evaluated at the beginning of treat-ment, 14 days, 3 months and one year after treatment. Results After 14 days of treatment, there was no statistically significant difference between the two groups in hearing and tinnitus （P＆gt;0.05）. Three months, one year after treat-ment, the effective rate in treatment group was 76.7%（23/3） and 83.3%（25/30）, significantly higher than 50.0%（15/30） and 60.0%（18/30） in the control group （P＆lt;0.05）. One year after treatment, 35 patients had concomitant symptoms of tinnitus （17 cases of the control group and 18 cases of the treatment group）, and the improvement rate of tinnitus [66.7% （12/18）] in treatment group was significantly higher than that in the control group [29.4% （5/17）], P＆lt;0.05. Conclusion Long-term use of ginkgo biloba extract can improve the long-term clinical efficacy in patients with sud-den deafness, which is worthy of clinical promotion.

关 键 词：银杏叶片 突发性耳聋 远期疗效 电测听 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]