基于文献的中药复方治疗肾纤维化用药规律研究  

A Study on Regularity of Compound Herbal Formulae for Renal Fibrosis Based on Literature

作　　者：戚莉[1] 易韬[2] 王晓柠[1] 刘平[1] 刘成海[1] 

机构地区：[1]上海中医药大学上海高校中医内科学E-研究院,上海201203 [2]复旦大学附属华山医院中西医结合研究所,上海200040

出　　处：《中国中医药信息杂志》2014年第12期34-37,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金(30901943);上海高校青年教师培养资助计划(2012年);上海高校E-研究院建设项目(E03008)

摘　　要：目的探讨中药复方治疗肾纤维化的用药规律。方法计算机检索中文科技期刊数据库、中国期刊全文数据库、中国生物医学文献服务系统、万方数据库中治疗慢性肾病肾纤维化的中药复方,建立相应数据库,采用频数分析、聚类分析、关联规则对复方中主要药物、药对(药组)规律进行分析。结果治疗肾纤维化38首中药复方涉及95味中药,总频次为362次。对高频药物聚类分析,主要为补益类、化瘀类、利湿类;经关联规则分析,共得药对规则18条,药组(3味药或4味药)规则31条。结论大多数医家治疗肾纤维化多用补益、活血化瘀药物。Objective To study the regularity of compound herbal formulae for renal fibrosis （RF）. Methods Compound herbal formulae published about the treatment of RF in databases of Chinese Science and Technology Periodical Database, CNKI, Chinese Biomedical Literature Service System, and Wanfang Databasewere searched and collected. A database was established for data mining by using frequency analysis, cluster analysis and association rule analysis. Regularity of key herbs and groups of herbs was discussed. Results There were 38 prescriptions （totally 95 herbs） in the compound herbal formulae for RF, and the total frequency was 362 times. High frequency herbs under cluster analysis were classified into 3 clusters including tonic, hemorheologic agent and promoting diuresis drugs. The rules in pair of herbs were 18, and rules in group of herbs were 31 （three or four medicinal herbs） by using association rule analysis. Conclusion Tonifying promoting blood circulation and removing blood stasis＆quot;is a common sense for treating RF.

关 键 词：肾纤维化 中药复方 频数分析 聚类分析 关联规则 数据挖掘 

分 类 号：R2-05[医药卫生—中医学] R277.52