镰形棘豆中鼠李柠檬素抗炎作用研究  

A Preliminary Study on Anti-inflammatory Effects of Rhamnocitrin from Oxytropis falcata Bunge

作　　者：古秋莉[1] 黄聪琳[1] 张丽 姜华 

机构地区：[1]甘肃省中医院,甘肃兰州730050 [2]甘肃中医药研究院,甘肃兰州730050

出　　处：《中国中医药信息杂志》2014年第12期48-50,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(81260633)

摘　　要：目的观察鼠李柠檬素的抗炎作用,为寻找镰形棘豆抗炎活性成分提供实验依据。方法分别将昆明种小鼠及Wistar大鼠,随机分为模型组、萘普生组和鼠李柠檬素高、中、低剂量组,灌胃给药,连续7 d。通过二甲苯诱导小鼠耳肿胀、冰醋酸诱导小鼠腹腔毛细管通透性、蛋清致大鼠足跖肿胀、棉球致大鼠肉芽肿的方法,观察鼠李柠檬素对急慢性炎症动物模型的影响。结果鼠李柠檬素各剂量组和萘普生组对上述4种方法所致的炎症反应有一定的抑制作用,与模型组比较差异有统计学意义(P<0.05)。其中鼠李柠檬素高剂量组和萘普生组对肿胀的抑制作用较强,2组比较差异有统计学意义(P<0.05)。结论鼠李柠檬素具有一定的抗炎作用,是镰形棘豆发挥抗炎作用的重要成分之一。Objective To observe the anti-inflammatory effects of rhamnocitrin in Oxytropis falcata Bunge;To provide experimental evidence for searching the anti-inflammatory active component of Oxytropis falcata Bunge. Methods Kunming mice or Wistar rats were randomly divided into model group, naproxen group and rhamnocitrin high-, medium-, low-dose groups, and corresponding medicines were administered by gavage for 7 days. Animal inflammatory models were established respectively by the mice ear swelling induced by dimethylbenzene, the mice abdominal capillary permeability induced by acetic acid, the rat paw edema created by injection of albumen and the rat granuloma induced by cotton pellet wool. The effects of rhamnocitrin on acute and chronic inflammatory animal models were observed. Results Different doses of rhamnocitrin groups could reduce the animal ear swelling, abdominal capillary permeability, paw edema and granuloma. Compared with the model group, there were obvious differences in rhamnocitrin groups （P＆lt;0.05）. High dose rhamnocitrin group and naproxen group showed relatively strong inhibition effects on swelling, with statistical significance （P＆lt;0.05）. Conclusion Rhamnocitrin has anti-inflammatory effects and is an important biological component of Oxytropis falcata Bunge.

关 键 词：镰形棘豆 鼠李柠檬素 抗炎作用 动物模型 

分 类 号：R285.5[医药卫生—中药学]