动态超声逆流提取技术在连花清瘟胶囊生产中的应用  

Application of Dynamic Ultrasound Countercurrent Extraction Technology in Industrialization of Lianhua Qingwen Capsule

作　　者：王玉峰[1] 王华[1] 路雅男 刘敏彦[1] 李向军[1] 范文成[1] 

机构地区：[1]石家庄以岭药业股份有限公司,河北石家庄050035

出　　处：《中国中医药信息杂志》2014年第12期72-75,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家科技重大专项-重大新药创制(2011ZX09201-201-27)

摘　　要：目的利用多指标研究动态超声逆流提取技术在连花清瘟胶囊生产中的应用。方法采用单因素试验考察超声温度和超声时间。在工艺参数固定的条件下,以干膏收率、有效成分含量、指纹图谱为指标,考察动态超声逆流提取工艺在溶剂消耗及提取时间上与原回流提取工艺的差异。结果动态超声逆流提取工艺在保证连花清瘟胶囊有效成分含量的基础上,可以显著降低乙醇消耗,节省提取时间。结论动态超声逆流提取工艺简便、快捷,应用于连花清瘟胶囊生产可大幅度降低生产成本,提高生产效率。Objective To study the application of dynamic ultrasound countercurrent extraction technology in industrialization of Lianhua Qingwen Capsule by multi-index optimization. Methods Ultrasonic temperature and ultrasonic time were investigated by using single factor design. The three factors of dry extract yield, the active ingredient content, and fingerprints were selected as the optimization indexes to investigate the solvent consumption and extraction time between the dynamic ultrasound countercurrent extraction process and the original reflux extraction process under the fixed conditions of process parameters. Results Compared with traditional reflux extraction technology, dynamic ultrasound countercurrent extraction technology effectively reduced the alcohol consumption and saved extraction time on the basis of guarantee of the active ingredient content. Conclusion Dynamic ultrasound countercurrent extraction process, with simple and fast advantages, can be used to Lianhua Qingwen Capsule production, which can significantly reduce production costs and increase productivity.

关 键 词：动态超声逆流提取 连花清瘟胶囊 产业化 

分 类 号：R283.5[医药卫生—中药学]