4-单取代-1,2,3-三氮唑的合成进展(Ⅰ)——通过环加成反应  

Advances in the synthesis of 4-monosubstituted-1,2,3-triazoles(Ⅰ)—through cycloaddition reactions

作　　者：江玉波[1] 殷云川 陈润奇[1] 雷鹏飞[1] 肖付俊 

机构地区：[1]昆明理工大学理学院,云南昆明650500

出　　处：《化学研究与应用》2014年第11期1695-1703,共9页Chemical Research and Application

基　　金：国家自然科学基金项目(21262020)资助;云南省科技厅项目(KKSY201207047)资助

摘　　要：1,2,3-三氮唑衍生物是近些年研究热点化合物之一,随着4-单取代型衍生物在医药、农药、材料等领域的广泛应用,该类化合物的合成及应用近些年引起了广大研究者的关注并获得了可喜进展。本文阐述了4-单取代-1,2,3-三氮唑衍生物的合成发展历史,着重综述了近十年来该类唑衍生物的合成发展情况。内容主要包括末端炔的环加成反应、由取代烯烃合成法及由3-芳基-2,3-二溴丙酸合成法。文章还包括一些合成方法及其产物的应用,并对一些重要的反应机理做了分析。文章最后对该类化合物的合成做了总结并展望了未来发展方向。1,2,3-Trizaole derivatives had become a research focus in recent years. Much attention had been paid to the synthesis of4-monosubstituted-1,2,3-trizaole derivatives with the development of their wide applications in the fields of medicine,pesticide,andmaterials. This review mainly described the synthesis history of these derivatives,focusing on the methods of cycloaddition reactionof terminal alkynes,preparation from substituted alkenes,and preparation from 3-aryl-2,3-dibromopropanoic acids in recent 10years. Relevant mechanisms and applications of some reactions and their products were also described. Finally,the further work neededto do and the development trends in the field of the synthesis of 4-monosubstituted-1,2,3-triazole derivatives were proposed.

关 键 词：4-单取代 1 2 3-三氮唑 末端炔 取代烯烃 3-芳基-2 3-二溴丙酸 

分 类 号：O621.3[理学—有机化学]