CCL18检测在儿童过敏性疾病中的临床价值  

Clinical value of CCL18 detection in children allergic diseases

作　　者：顾猛[1] 丁翠君[1] 陆冬明[1] 高春标 陈朝[1] 

机构地区：[1]常州市儿童医院检验科,江苏常州213003

出　　处：《国际检验医学杂志》2014年第20期2737-2738,共2页International Journal of Laboratory Medicine

基　　金：南通市科技项目(HS2011060)

摘　　要：目的探索趋化因子CCL18在儿童过敏性疾病发生、发展过程中的作用。方法利用ELISA法对诊断为过敏性哮喘、过敏性鼻炎、过敏性眼结膜炎的患儿和同期健康体检学生的血清CCL18水平进行检测,并在临床治疗6个月后重新复检该指标。结合临床相关检查资料,对检测结果采用SPSS18.0统计软件进行分析,采用t检验,P<0.05为差异有统计学意义。结果过敏性哮喘、过敏性鼻炎和过敏性眼结膜炎3组患儿的CCL18水平与健康对照组相比较,均明显升高,差异有统计学意义(P<0.05);轻、中度和重症患儿两组比较,重症患儿组CCL18水平升高的幅度明显高于轻、中度患儿组,差异有统计学意义(P<0.05);治疗6个月后,3组患儿的CCL18水平较治疗前均有明显的下降,差异有统计学意义(P<0.05)。结论 CCL18水平与患儿病情的严重程度明显相关,治疗后明显下降,提示CCL18的检测在过敏性患儿的病情诊断、病情严重程度的评估和治疗效果的监测过程中有着重要的临床价值。Objective To explore the role of chemokine CCL18 in the occurrence and development of children allergic diseases. Methods The serum levels of CCL18 in 87 children cases of allergic asthma,64 cases of allergic rhinitis,46 cases of allergic con-junctivitis and contemporaneous 50 health students with physical examination as the control group were measured by ELISA and re-measured after 6-month treatment.The detection results were statistically analyzed with combining the clinical related detection data by adopting SPSS18.0 statistical software and t-test.Results The serum levels of CCL18 in the children allergic asthma,allergic rhinitis and allergic conjunctivitis groups were remarkably higher than those in the control group with statistical differences（P 〈0.05）;the levels of CCL18 in the severe groups were remarkably higher than those in the mild and moderate groups with statistical difference（P 〈0.05）;the levels of CCL18 after 6-month treatment in 3 groups were significantly decreased compared with before treatment with statistical difference（P 〈0.05）.Conclusion The serum level of CCL18 is significantly associated with the severity of illness and significantly decreased after treatment,which indicating that the CCL18 detection has the important value in the diag-nosis,severity evaluation and treatment effect monitoring of children allergic diseases.

关 键 词：趋化因子CCL18 过敏性哮喘 过敏性鼻炎 过敏性眼结膜炎 

分 类 号：R446.6[医药卫生—诊断学]