GFAP、MBP在早期脑挫裂伤诊断中的价值  

Value of GFAP and MBP in diagnosing early brain contusion and laceration

作　　者：李庆禄[1] 李宁[1] 王文智[1] 李伟[1] 李光杰[2] 

机构地区：[1]哈励逊国际和平医院检验科,河北衡水053000 [2]哈励逊国际和平医院神经外科,河北衡水053000

出　　处：《国际检验医学杂志》2014年第20期2756-2757,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨血清神经胶质纤维酸性蛋白(GFAP)、髓鞘碱性蛋白(MBP)联合检测在早期脑挫裂伤患者诊断中的价值。方法采用酶联免疫吸附实验(ELISA)法检测血清GFAP、MBP浓度,多组间比较采用单因素方差分析,两两比较采用q检验分析脑挫裂伤患者与健康人群间的差异。结果血清GFAP、MBP浓度,轻、重型颅脑损伤组与健康对照组3组间统计学分析差异有统计学意义(P<0.05);对照组与轻型颅脑损伤组比较差异有统计学意义(P<0.05);轻、重型颅脑损伤组比较差异有统计学意义(P<0.05);对照组与重型颅脑损伤组比较差异有统计学意义(P<0.05)。脑挫裂伤患者早期血清GFAP、MBP浓度明显高于对照组,且损伤越重升高越明显。结论血清GFAP、MBP水平联合检测可以作为早期脑挫裂伤诊断及评估损伤程度的辅助指标。Objective To investigate the diagnostic value of the combined detection of serum glial fibrillary acidic protein （GFAP）and myelin basic protein （MBP）in the patients with early brain contusion and laceration.Methods ELISA was adopted to detect serum GFAP and MBP.The one-way ANOVA analysis was adopted to conduct the comparison among groups and the q test was adopted to conduct the pairwise comparison for analyzing the differences between the brain contusion and laceration patients with the healthy population.Results The serum GFAP and MBP levels had statistically significant differences among the mild craniocerebral injury group,severe craniocerebral injury group and the healthy control （P 〈0.05）;which had statistically signifi-cant differences between the control group and the mild craniocerebral injury group（P 〈0.05）;which had statistically significant differences between the mild craniocerebral injury group and the severe craniocerebral group （P 〈0.05 ）;which had statistically significant differences between the control group and the severe craniocerebral injury group （P 〈0.05）.The serum GFAP and MBP levels in the early stage of brain contusion and laceration were significantly higher than those in the control group,moreover,the more severe the injury,the more obvious the increase of serum GFAP and MBP.Conclusion The combined detection of serum GFAP and MBP can be regarded as the auxiliary indexes for the early diagnosis of early brain contusion and laceration and the eval-uation of the injury degree.

关 键 词：神经胶质纤维酸性蛋白 髓鞘碱性蛋白 脑挫裂伤 辅助诊断 

分 类 号：R651.1[医药卫生—外科学]