8546例泌尿生殖道标本解脲支原体和人型支原体检测及药敏分析  

Detection and drug susceptibility of Ureaplasma urealyticum and Mycoplasma hominis in 8546 cases of genitourinary tract specimen

作　　者：李进[1] 黎敏[1] 鲁卫平[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所检验科,重庆400042

出　　处：《国际检验医学杂志》2014年第20期2762-2764,共3页International Journal of Laboratory Medicine

摘　　要：目的了解本院泌尿生殖道炎症患者支原体分离率及对12种抗菌药物的体外灵敏度,以指导临床合理用药。方法采用支原体培养、鉴定和药敏试剂盒对本院收集到的8 546例泌尿生殖道标本进行培养和体外药敏试验。结果 8 546例患者标本中支原体阳性3 237例(37.9%),其中单纯解脲支原体(Uu)阳性2 897例(89.5%)、单纯人型支原体(Mh)阳性39例(1.2%)、Uu和Mh均阳性301例(9.3%),两两比较,差异有统计学意义(P<0.05);药敏结果显示,2 897例Uu对抗菌药物敏感率由高到低的前三位依次为:交沙霉素(98.4%)、强力霉素(97.9%)、美满霉素(97.6%);耐药率由高到低的前三位依次为:环丙沙星(71.8%)、螺旋霉素(46.8%)、氧氟沙星(35.6%)。39例Mh对抗菌药物敏感率由高到低的前三位依次为:交沙霉素(96.7%)、强力霉素(91.2%)、美满霉素(90.8%),耐药率由高到低依次为:氧氟沙星(68.9%)、环丙沙星(67.8%)、罗红霉素(54.2%)。301例Uu+Mh对抗菌药物敏感率由高到低的前三位依次为:强力霉素(95.2%)、美满霉素(94.8%)、交沙霉素(92.1%),耐药率由高到低的前三位依次为:环丙沙星(83.3%)、氧氟沙星(80.1%)和左氧氟沙星(76.3%)。结论 Uu和Mh是泌尿生殖道感染中常见的病原体,本院泌尿生殖道标本分离到的支原体以Uu为主,所以治疗支原体感染时应把交沙霉素、强力霉素、美满霉素等灵敏度较高的药物作为首选。Objective To investigate the mycoplasma separation rate in the patient with genitourinary tract inflammation in our hospital and the in vitro sensitivity to 12 kinds of antibacterial drugs for guiding clinical rational drug use.Methods 8 546 cases of genitourinary tract specimen were collected from our hospital STD clinical department and performed the culture and the in vitro drug susceptibility test by adopting the mycoplasma culture,identification and drug susceptibility integration reagent kit.Results Among 8 546 cases of patient specimen,3237 cases were mycoplasma positive,in which 2 897 cases （89.5%）were simple Ureaplas-ma urealyticum（Uu）positive,39 cases （1.2%）were simple Mycoplasma hominis （Mh）positive and 301 cases （9.3%）were Uu and Mh positive,there was statistically significant difference between any two groups （P 〈0.01 ）;the drug susceptibility test showed that the top 3 of sensitivity rates to antibacterial drugs in 2 897 cases of Uu infection from high to low were josamycin （98.4%）,doxycline （97.9%）and minomycin （97.6%）,the top 3 of drug resistance rates from high to low were ciprofloxacin （71.8%）,spiramycin （46.8%）and ofloxacin （35.6%）.The top 3 of sensitivity rates to antibacterial drugs in 39 cases of Mh infec-tion from high to low were josamycin （96.7%）,doxycline （91.2%）and minomycin（90.8%）,and the top 3 of drug resistance rates were ofloxacin （68.9%）,ciprofloxacin （67.8%）and roxithromycin （54.2%）.The top 3 of sensitivity rates to antibacterial drugs in 301cases of Uu and Mh infection from high to low were doxycline （95.2%）,minomycin （94.8%）and josamycin （92.1%）,and the top 3 of drug resistance rates from high to low were ciprofloxacin （83.3%）,ofloxacin （80.1%）and levofloxacin （76.3%）.Conclu-sion Uu and Mh are the common pathogens of genitourinary tract infection.Mycoplasma isolated from genitourinary tract speci-mens in our hopsital is dominated by Uu,so the drugs with higher sensitivity such as jo

关 键 词：解脲支原体 人型支原体 药物灵敏度 

分 类 号：R446.5[医药卫生—诊断学]