L-ProT catalyzed highly regioselective N-alkoxyalkylation of purine rings with vinyl ethers  

作　　者：Jian-Jun Li Xing-Xing Gui 

机构地区：[1]Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education,College of Pharmaceutical Sciences,Zhejiang University of Technology

出　　处：《Chinese Chemical Letters》2014年第10期1341-1345,共5页中国化学快报（英文版）

基　　金：the Natural Science Foundation of Zhejiang Province(No.LY13B020015);Zhejiang Key Innovation Team of Green Pharmaceutical Technology(No.2012R10043-07) for financial support

摘　　要：An efficient and regioselective synthesis of N-9 alkoxyalkylated purine nucleoside derivatives was achieved via the N-alkoxyalkylation of purine rings with vinyl ethers catalyzed by L-ProT.The advantages of this protocol include good to excellent yield,mild reaction condition,and simple manipulation.A plausible mechanism for the transformation was given.An efficient and regioselective synthesis of N-9 alkoxyalkylated purine nucleoside derivatives was achieved via the N-alkoxyalkylation of purine rings with vinyl ethers catalyzed by L-ProT.The advantages of this protocol include good to excellent yield,mild reaction condition,and simple manipulation.A plausible mechanism for the transformation was given.

关 键 词：L-Proline triflate Regioselectivity Purine Vinyl ether Addition reaction 

分 类 号：O629.74[理学—有机化学]