Efficient synthesis of chromenopyridine and chromene via MCRs  

作　　者：Hai-Feng Gan Wei-Wei Cao Zheng Fang Xin Li Shi-Gui Tang Kai Guo 

机构地区：[1]College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University [2]School of Pharmaceutical Sciences,Nanjing Tech University

出　　处：《Chinese Chemical Letters》2014年第10期1357-1362,共6页中国化学快报（英文版）

基　　金：supported by the National High Technology Research and Development Program of China(863 Program,No.2012AA02A701);the National High Technology Research and Development Program of China(863 Program,No. 2013AA031901);Program for Changjiang Scholars and Innovative Research Team in University(No.IRT1066)

摘　　要：MCRs for preparation of chromenopyridines under reflux conditions and chromenes at room temperature conditions from different salicylaldehydes,malononitrile and different thiols（mol ratio- 1：2：1） were established.Mechanistic investigation suggests that the MCRs undergo different pathways at different temperatures and catalyzed by different organic bases.The structure of chromenopyridine and chromene are confirmed by crystal X-ray crystallography.MCRs for preparation of chromenopyridines under reflux conditions and chromenes at room temperature conditions from different salicylaldehydes,malononitrile and different thiols（mol ratio- 1：2：1） were established.Mechanistic investigation suggests that the MCRs undergo different pathways at different temperatures and catalyzed by different organic bases.The structure of chromenopyridine and chromene are confirmed by crystal X-ray crystallography.

关 键 词：Multi-component reaction Chromenopyridine Chromene Mechanistic study Reaction condition 

分 类 号：O621.3[理学—有机化学]