多囊卵巢综合征不孕患者血清生长素水平变化及其与胰岛素抵抗的关系  

Relation between serum Ghrelin level and insulin resistance in infertility patients with PCOS

作　　者：黄红艺[1] 何冰[1] 莫云[1] 刘杨桦[1] 张团英[2] 张凤兰[2] 

机构地区：[1]广西壮族自治区人民医院生殖中心,南宁530021 [2]广东医学院附属医院妇产科,湛江524000

出　　处：《中国临床新医学》2014年第10期902-904,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西卫生厅科研课题(编号:桂卫Z2013383)

摘　　要：目的研究多囊卵巢综合征(PCOS)不孕患者血清生长素(Ghrelin)水平的变化及其与胰岛素抵抗(IR)的关系。方法选择98例PCOS不孕患者(PCOS组)及72例非PCOS不孕患者(非PCOS组),比较两组患者的体重指数(BMI)、血清Ghrelin、血糖、胰岛素、稳态模型胰岛素抵抗指数(HOMA-IR)间的相互关系。血清Ghrelin采用ELISA法测定,空腹血浆葡萄糖(FPG)采用葡萄糖氧化酶法测定,空腹胰岛素(FIns)采用化学发光法测定。结果 PCOS组血清Ghrelin水平(pg/ml)明显低于非PCOS组[(442.56±221.71)vs(697.41±157.84),P<0.05]。PCOS组的HOMA-IR高于非PCOS组[(3.84±1.23)vs(2.14±0.77),P<0.05]。Person相关分析表明,PCOS组血清Ghrelin水平与HOMA-IR呈负相关(r=-0.48,P<0.01)。结论PCOS不孕患者血清Ghrelin水平降低,并且其降低与IR密切相关。提示Ghrelin可能参与PCOS不孕患者胰岛素抵抗的发生与发展。Objective To explore the relationship between serum Ghrelin level and insulin resistance in in-fertility patients with PCOS.Methods Ninety-eight cases of PCOS （ PCOS group） and seventy-two cases of non PCOS （ non PCOS group） for first time visiting our hospital due to infertility from January 2010 to December 2012 were selected.The BMI, serum Ghrelin level, and the related anthropometric indexes were detected.Results The serum Ghrelin levels in PCOS patients were lower than non PCOS patients [ （ 442.56 ±221.71 ） pg/ml vs （ 697.41 ± 157.84）pg/ml, P〈0.05].The HOMA-IR was higher in PCOS group compared to non PCOS group[（3.84 ±1.23） vs （2.14 ±0.77）, P〈0.05].Pearson correlation analysis showed that serum Ghrelin level was negatively correlated with HOMA-IR in PCOS patients（r=-0.48, P〈0.01）.Conclusion The serum Ghrelin level in infertility patients with PCOS is evidently lower than that in non PCOS infertility patients.Ghrelin level was negatively correlated with HOMA-IR in PCOS patients.Thus indicated that Ghrelin may promote the development of IR in infertility patients with PCOS.

关 键 词：多囊卵巢综合征 胰岛素抵抗 不孕 生长素 

分 类 号：R711[医药卫生—妇产科学]