慢性阻塞性肺疾病急性加重期患者血浆N端脑利钠肽前体水平的变化及应用价值  

The clinical value of changes of N-terminal pro-brain natriuretic peptide levels in patients with acute exacerbation chronic obstructive pulmonary disease

作　　者：张立涛[1] 许宁[1] 李素彦[1] 齐亚超[2] 

机构地区：[1]河北省人民医院急诊科,石家庄市050051 [2]河北省人民医院神经内科,石家庄市050051

出　　处：《河北医药》2014年第22期3385-3387,共3页Hebei Medical Journal

摘　　要：目的比较慢性阻塞性肺疾病急性加重(AECOPD)患者综合治疗前后血浆N端脑利钠肽前体(NT-proBNP)水平的变化并探讨其临床应用价值。方法 30例满足条件的AECOPD患者,分别检测入院时及24 h治疗后患者血浆NT-proBNP水平,急性生理学及慢性健康状况评分Ⅱ(APACHEⅡ评分)及肺动脉压(PAP)水平。结果入院时患者NT-proBNP水平与APACHEⅡ评分及PAP值呈正相关(分别为r=0.763和r=0.888,均P<0.01),24 h治疗后患者总体NT-proBNP水平、APACHEⅡ评分及PAP值相比治疗前明显下降,差异有统计学意义(P<0.05)。治疗后患者NT-proBNP水平与APACHEⅡ评分及PAP值仍呈正相关(r值分别为0.609和0.821,P<0.01)。结论血浆NT-proBNP水平与APACHEⅡ评分及PAP值具有良好的正相关性,可用于AECOPD患者病情严重程度评估。Obej ctive To investigate the clinical significance of N-terminal pro-brain natriuretic peptide （ NT-proBNP） levels in patients with acute exacerbation chronic obstructive pulmonary disease （ AECOPD） M.ethods Thirty patients with AECOPD were enrolled in the study .The plasma levels of NTp-roBNP,APACHEⅡscores and pulmonary artery pressures （ PAP） were measured before treatment and 24 hours after treatment for all the patients .Results The NT -proBNP levels were positively correlated to APACHEⅡscores （ r =0.763, P 〈0.01） and to PAP value （ r =0.888, P 〈0.01） in patients with AECOPD before treatment.However after 24-hour treatment,NT-proBNP levels,APACHE Ⅱ scores as well as PAP value were significantly decreased,as compared with those before treatment （ P 〈0.05）.After treatment NT-proBNP levels were still positively correlated to APACHE Ⅱ scores （r =0.609, P 〈0.01） and to PAP value （ r =0.821, P 〈0.01）.Conclusion There are favourable positive correlations between NT -proBNP levels and APACHE Ⅱscores as well as PAP value,which can reflect the severity of pathogenetic condition of patients with AECOPD.

关 键 词：N端脑利钠肽前体 慢性阻塞性肺疾病 急性生理学及慢性健康状况评分 肺动脉压 

分 类 号：R563[医药卫生—呼吸系统]