吡啶胺帕米膦酸的合成与表征  

Synthesis and Characterization of Dipicolylamine Pamidronate

作　　者：刘红[1,2] 林建国[2] 邱玲[2] 罗世能[1,2] 夏咏梅 

机构地区：[1]江南大学化学与材料工程学院,江苏无锡214122 [2]江苏省原子医学研究所卫生部核医学重点实验室,江苏省分子核医学重点实验室,江苏无锡214063

出　　处：《江南大学学报（自然科学版）》2014年第5期602-606,共5页Joural of Jiangnan University (Natural Science Edition)　

基　　金：国家自然科学基金项目(21371082);江苏省医学重点人才基金项目(RC2011097)

摘　　要：以帕米膦酸和2-氯甲基吡啶为原料,在碱性条件下以水为溶剂,成功合成了吡啶胺帕米膦酸。通过制备型高效液相分离提纯,反应收率达85%,纯度达99%。通过红外光谱、元素分析、质谱、核磁共振谱确证吡啶胺帕米膦酸的结构,并对合成条件和分离提纯条件进行探讨。Dipicolyamine pamindronate was synthesized from pamidronate and 2-（chloromethyl） pyridine hydroehloride in hydroxide sodium solution maintaining the pH of the solution at 12 at room temperature. The yield was 85% by preparative RP-HPLC and the purity was 99%. The structures was characterised by IR, elemental analysis, ESI-MS spectroscopy, l H-NMR and 13C-NMR. The synthesis and purification conditions were discussed and optimized.

关 键 词：吡啶胺帕米膦酸 合成 表征 条件优化 

分 类 号：O626.32[理学—有机化学]