桂枝茯苓胶囊对乳腺增生大鼠性激素水平和乳腺组织的影响  

Effects of Guizhi Fuling capsule on sex hormone levels and breast issue morphology of mammary gland hyperplasia model rats

作　　者：常秀娟[1,2,3] 周军[1,2,3] 张帅[1,2,3] 陈健[1,2,3] 陈春苗[1,2,3] 王振中[1,2,3] 萧伟[1,2,3] 

机构地区：[1]江苏康缘药业股份有限公司,江苏连云港222001 [2]中药制药过程新技术国家重点实验室,江苏连云港222001 [3]江苏省企业院士工作站,江苏连云港222001

出　　处：《中国中药杂志》2014年第21期4139-4142,共4页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2011ZX09101403)

摘　　要：目的:研究桂枝茯苓胶囊对乳腺增生大鼠的血清性激素水平及乳腺组织形态学的影响。方法:采用苯甲酸雌二醇注射液对SD雌性未孕大鼠按0.5 mg·kg-1肌肉注射制作乳腺增生模型,观察受试药桂枝茯苓胶囊2.0,1.0,0.5 g·kg-1和阳性对照药乳癖消0.5 g·kg-1灌胃给药5周后对乳腺增生模型大鼠乳头直径、高度,乳腺组织形态学的变化和性激素水平变化。结果:桂枝茯苓胶囊可改善大鼠乳头肿胀度,减轻乳腺组织的病变,降低血清雌二醇(E2)和升高孕酮(P)水平。结论:桂枝茯苓胶囊改善乳腺病理变化,调节大鼠性激素水平可能是治疗乳腺增生疾病的重要机制。Objective： To research the effects of Guizhi Fuling capsule on sex hormones levels in blood serum and breast issue morphology of hyperplasia of mammary glands model rats. Method： The unpregnancy SD rat models of hyperplasia of mammary glands were established by injecting 0. 5 mg ·kg^-1 benzoate estradiol. After five weeks doses, the effects of Guizhi Fuling capsule 2. 0,1. 0, 0. 5 g·kg^-1 and Rupixiao tablet 0. 5 g·kg^-1 on the changes of papilla diameter, height and breast issue morphology of the naimal models were explored, and sex hormoneslevels in blood serum were measured. Result： Guizhi Fuling capsule can inhibitnipple swell, improve breast tissue morphology pathological profiles of the animalmodels, and decrease oestradiol（E2） level and increase progesterone （P） level in blood serum. Conclusion： These results suggested that Guizhi Fuling capsule could, improve mammary gland pathological profiles. Regulating sex hormone levels may be its important mechanism for treatment ofhyperplasia of mammary glands.

关 键 词：桂枝茯苓胶囊 乳腺增生 性激素 

分 类 号：R271.44[医药卫生—中医妇科学]