桑黄抗肿瘤及其作用机制的研究进展  

Research progress on antitumor effects and mechanisms of phellinus

作　　者：高雯雯[1] 张娜[1] 俞淑文[2] 

机构地区：[1]山东大学药学院,山东济南250012 [2]山东大学附属济南市中心医院,山东济南250013

出　　处：《中国中药杂志》2014年第21期4165-4168,共4页China Journal of Chinese Materia Medica

基　　金：山东省科技发展计划项目(2012GSF1191);济南市科技计划项目(201101025)

摘　　要：桑黄(phellinus)作为一种名贵的真菌类药材,具有抗肿瘤、抗肝纤维化、抗氧化等多种生理功能。桑黄含有多糖类、甾体类、萜类、黄酮类、吡喃酮类、呋喃类、生物碱类等物质。其中多糖类提取物具有明显抗肿瘤作用,成为当前抗癌药物研究的热点;桑黄的其他提取物如乙酸乙酯提取物等也表现出抗癌活性。该文综述桑黄不同提取物的抗肿瘤作用,着重介绍其抗肿瘤机制的研究进展,为进一步开发桑黄奠定基础。Phellinus is a kind of rare medicinal fungus that has a variety of physiological activities include anti-cancer, antiliver fibrosisa, antioxidant and so on. Phellinus contains polysaccharides, steroids, terpenoids, flavonoids, pyrone, furan, alkaloids and other substances. Polysaccharide extracts of phellinus showed obvious antitumor effect and has been a hot research field in recent years. It was also found other extracts of phellinus such as ethyl acetate extract exhibited anticancer activity. Thus, the antitumor effect of different extract, especially the anti-cancer mechanism were discussed in this review.

关 键 词：桑黄 多糖 提取物 抗肿瘤 作用机制 

分 类 号：R285[医药卫生—中药学]