盐酸曲马多导致呼吸道痉挛的药学分析与临床处理  

Analysis and clinical treatment of respiratory tract spasms induced by tramadol hydrochloride

作　　者：张文静[1] 万思慧 王卓[1] 夏阳[3] 白冲[3] 

机构地区：[1]第二军医大学长海医院药学部,上海200433 [2]中国药科大学,江苏南京210009 [3]第二军医大学长海医院呼吸内科,上海200433

出　　处：《中国药物应用与监测》2014年第5期297-299,共3页Chinese Journal of Drug Application and Monitoring

基　　金：第二军医大学长海医院"1255"学科特色提升项目(CH125520400)

摘　　要：1例气管腺样囊腺癌术后患者超剂量使用盐酸曲马多后出现气喘和气急症状。临床药师通过对其进行重点药学监护,查阅国内外相关文献,发现超剂量(>1000 mg·d-1)或肝功能受损患者使用盐酸曲马多后可能会出现呼吸系统症状,表现为气喘、气急以及呼吸抑制症状。并对曲马多药理学机制及其不良反应处置、体内药代动力学特点等进行分析。患者停用曲马多后,气喘、气急症状得以缓解。One tracheal adenoid cystic carcinoma patient after surgical operation developed asthma and shortness of breath because of over dose use of tramadol hydrochloride. The clinical pharmacists took pharmaceutical care for this specific case. According to literature from domestic and aboard, the patient using high dose of tramadol（〉1000 mg·d^-1） or the patient using tramadol with liver injury could develop asthma, shortness of breath and respiratory depression symptoms. The pharmacists discussed the pharmacology and pharmacokinetics of tramadol and treatment of adverse drug reaction caused by tramadol with doctors. Symptoms of asthma and shortness of breath eventually relieved after withdrawal of tramadol.

关 键 词：曲马多 呼吸道痉挛 临床药师 药学监护 

分 类 号：R971[医药卫生—药品]