Enhanced in vitro anticancer activity of quercetin mediated by functionalized CdTe QDs  

作　　者：WU ChunHui SHI LiXin WU ChangYu GUO DaDong SELKE Matthias WANG XueMei 

机构地区：[1]School of Life Science and Technology, University of Electronic Science and Technology of China [2]State Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University [3]Department of Chemistry and Biochemistry, California State University

出　　处：《Science China Chemistry》2014年第11期1579-1588,共10页中国科学（化学英文版）

基　　金：supported by the National Basic Research Program of China(2010CB732404);the National Natural Science Foundation of China(21175020);the Project of the Ministry of the Science & Technology of China(2007AA022007);the Natural Science Foundation of Jiangsu Province(BK2008149);the support of National Natural Science Foundation of China(81101147);the China Postdoctoral Science Foundation(2011M501297);the China Postdoctoral Science Special Foundation(2012T50773);the Fundamental Research Funds for the Central Universities(ZYGX2011J099);the support by the State Key Laboratory of Bioelectronics,Southeast University,Nanjing 210096,China(2011E09);the Research Start-up Grants for New Science Faculty of University of Electronic Science and Technology of China(Y02002010901035);support from the United States NSF-CREST program(HRD0932421)

摘　　要：We report in this study the effects of red-emitting CdTe QDs capped with cysteamine(Cys-CdTe) on the in vitro anticancer activity of the well-known flavenoid quercetin(Qu). Various techniques, including the methylthiazolyldiphenyl-tetrazolium bromide assay, the real-time cell electronic sensing system, the optical and fluorescence imaging, and electrochemical methods have been utilized to study the potential interactions of Cys-CdTe QDs with Qu. The observations demonstrate that the safe-dosage Cys-CdTe QDs can greatly improve the drug uptake and enhance the inhibition efficiency of Qu towards the proliferation of cancer cells such as HepG2 cells. This study implies that Cys-CdTe QDs may be used for cancer therapy and that they exert a synergic anticancer effect when bound to drug molecules.We report in this study the effects of red-emitting CdTe QDs capped with cysteamine（Cys-CdTe） on the in vitro anticancer activity of the well-known flavenoid quercetin（Qu）. Various techniques, including the methylthiazolyldiphenyl-tetrazolium bromide assay, the real-time cell electronic sensing system, the optical and fluorescence imaging, and electrochemical methods have been utilized to study the potential interactions of Cys-CdTe QDs with Qu. The observations demonstrate that the safe-dosage Cys-CdTe QDs can greatly improve the drug uptake and enhance the inhibition efficiency of Qu towards the proliferation of cancer cells such as HepG2 cells. This study implies that Cys-CdTe QDs may be used for cancer therapy and that they exert a synergic anticancer effect when bound to drug molecules.

关 键 词：quantum dots QUERCETIN NANOCOMPOSITES cancer cell inhibition 

分 类 号：TQ460.1[化学工程—制药化工]