小儿肺炎患儿微量元素、免疫球蛋白与易感因素的临床研究  

Clinical research on microelement and immune globulin and predisposing factors of infantile pneumonia

作　　者：宁君[1] 牛峰海[1] 

机构地区：[1]济宁医学院附属医院,272000

出　　处：《中国实用医药》2014年第28期26-28,共3页China Practical Medicine

摘　　要：目的探讨小儿肺炎患儿的微量元素、免疫球蛋白与易感因素。方法收治呼吸道反复感染患儿（观察组）及门诊体检的健康儿童（对照组）各80例,采用自制的小儿肺炎易感因素调查表,记录两组儿童血常规、血金属元素及血免疫球蛋白等检查结果。采用χ2检验和t检验进行易感因素的单因素分析,采用非条件Logistic回归模型进行易感因素的多因素分析。结果观察组的血钙、铁元素、血IgA和IgG明显低于对照组,差异具有统计学意义（P〈0.05）。将与小儿肺炎相关的因素引入多因素Logistic回归分析,结果显示：胎次≥3次（OR=2.988,95%CI 1.249-5.147）、被动吸烟（OR=6.812,95%CI 2.143-13.764）、低钙血症（OR=3.304,95%CI 1.203-6.056）、血清IgA〈230 mg/L（OR=5.237,95%CI1.103-10.721）和IgG〈5 g/L（OR=5.408,95%CI 1.282-11.302）、抗生素与激素的使用（OR=8.542,95%CI3.762-16.997）、生活环境（幼儿园）（OR=3.251,95%CI 1.377-6.223）为小儿肺炎的独立易感因素。结论小儿肺炎与多种因素有关,应针对易感因素做好预防工作。Objective To explore microelement and immune globulin and predisposing factors of infantile pneumonia. Methods Children with repeated respiratory infection in our hospital（observation group） and outpatient healthy children（control group） were selected as 80 cases in each group. The blood routine, blood metallic elements, and blood immune globulin of the two groups were recorded using self-designed susceptibility factors questionnaire. The analysis single factor of predisposing factors was made by χ2 test and t test. The multifactors of predisposing factors were analyzed by unconditioned Logistic regression model. Results Blood calcium, iron, IgA and IgG of the observation group were obviously lower than those of the control group, and the difference had statistical significance（P〈0.05）. The infantile pneumonia related factors analyzed by multi-factor Logistic regression analysis showed the independent predisposing factors of infantile pneumonia were ≥ 3 times（OR=2.988, 95%CI 1.249-5.147）, passive smoking（OR=6.812, 95%CI 2.143-13.764）, hypocalcemia（OR=3.304, 95%CI 1.203-6.056）, serum IgA〈230 mg/L（OR=5.237, 95%CI 1.103-10.721）, IgG〈5 g/L（OR=5.408, 95%CI 1.282-11.302）, the use of antibiotics and hormones（OR=8.542, 95%CI 3.762-16.997）, and living environment（kindergarten）（OR=3.251, 95%CI 1.377-6.223）. Conclusion A variety of factors are related to infantile pneumonia, and the prevention work should be made according to predisposing factors.

关 键 词：小儿肺炎 微量元素 免疫球蛋白 易感因素 

分 类 号：R725.6[医药卫生—儿科]