T淋巴细胞计数与严重肺炎患者的相关性分析  

Relationship between T lymphocyte counts and severity of pneumonia

作　　者：王逸群[1] 熊辉[1] 郑波[1] 

机构地区：[1]北京大学第一医院急诊科,北京100034

出　　处：《中华医院感染学杂志》2014年第21期5330-5332,共3页Chinese Journal of Nosocomiology

基　　金：中美新发和再发传染病合作基金资助项目(5U2GGH000018)

摘　　要：目的探讨CD4+T淋巴细胞计数与肺炎患者严重程度的相关性,了解其与预后的关系。方法回顾性分析2012年12月-2013年12月100例医院住院的肺炎患者临床资料,根据CD4+T淋巴细胞计数分为200/mm3和<200/mm3两组,分别评估肺炎严重程度;同时比较两组间休克发生率、进行机械通气、ICU治疗时间及病死率;对65岁和<65岁两个年龄段患者的CD4+T淋巴细胞计数进行比较,并分别评估两个年龄段肺炎严重程度。结果 CURB-65和PSI评分CD4+T淋巴细胞计数<200/mm3组肺炎患者高于200/mm3组,差异有统计学意义(P<0.05),该组患者休克发生率、机械通气率更高、住ICU时间更长、病死率更高(P<0.05);65岁和<65岁两个年龄段的患者CD4+T淋巴细胞计数差异无统计学意义;在两个年龄段中分别比较,CD4+T淋巴细胞计数<200/mm3组肺炎患者病死率均较CD4+T淋巴细胞计数200/mm3组患者高(P<0.05)。结论肺炎患者发病初期CD4+T淋巴细胞降低的患者肺炎更重,预后更差,提示肺炎初期测定CD4+T淋巴细胞有预测疾病严重程度及预后的作用。OBJECTIVE To explore the relationship between the CD4 ＋ T lymphocytes counts and the severity of pneumonia and understand its correlation with the prognosis .METHODS The clinical data of 100 pneumonia patients who were hospitalized from Dec 2012 to Dec 2013 were retrospectively analyzed ,then the patients were divided into the no less than 200 /mm3 group and the less than 200 /mm3 group according to the CD4 ＋ T lymphocytes counts ,the severity of the pneumonia was evaluated ;the incidence of shock ,mechanical ventilation , length of ICU stay ,and mortality were compared between the two groups ;the CD4 ＋ T lymphocytes counts were compared between the patients aged no less than 65 years old and the patients aged less than 65 years old ,and the severity of pneumonia of the two age groups of patients was evaluated .RESULTS The CURB-65 score and PSI score of the patients with the CD4 ＋ T lymphocytes counts less than 200/mm3 were higher than those of the patients with the CD4 ＋ T lymphocytes counts no less than 200/mm3 ,there was statistically significant difference （P〈0 .05） .The incidence of shock ,rate of mechanical ventilation ,and mortality were higher in the patients with the CD4 ＋ T lymphocytes counts less than 200/mm3 than in the patients with the CD4 ＋ T lymphocytes counts no less than 200 /mm3 ,and the length of ICU stay of the patients with the CD4 ＋ T lymphocytes counts less than 200/mm3 was longer than that of the patients with the CD4 ＋ T lymphocytes counts no less than 200 /mm3 .There was no statistically significant difference in the CD4 ＋ T lymphocytes counts between the patients aged no less than 65 years old and the patients aged less than 65 years old .As compared with the two age groups of patients ,the mortality of the patients with the CD4 ＋ T lymphocytes counts less than 200 /mm3 was higher than that of the patients with the CD4 ＋ T lymphocytes counts no less than 200 /mm3 （P〈0 .05） .CONCLUSIONS In the early stage of onset of pneumonia ,it is more severe in th

关 键 词：肺炎 CD4 + T淋巴细胞计数 肺炎严重程度 

分 类 号：R563.1[医药卫生—呼吸系统]