不同维生素D注射剂对健康女性血25羟维生素D水平的影响  

The efficiency of different Vitamin D in raising serum 25-hydroxyvitamin D status of Health Women

作　　者：苟晓琴[1] 李世云[1] 李勤[1] 甘莉[1] 饶进[1] 熊萍[1] 李强[1] 李龙英[1] 廖琬 

机构地区：[1]成都大学附属医院,成都市610081

出　　处：《临床合理用药杂志》2014年第32期11-12,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的比较维生素D2注射液与维生素D3注射液在治疗健康女性维生素D缺乏或不足时对血25羟维生素D水平的影响。方法选择常住成都市且年龄在40-55岁的健康女性94名,随机将其分为D2组和D3组各47例。D2组给予维生素D2注射液,每次7.5mg（30万U）,每2周注射1次,共注射4次;D3组给予维生素D3注射液,每次7.5mg（30万U）,每2周注射1次,共注射4次。分别于治疗前、最后1次注射后2周采静脉血测定血清25羟维生素D,血清钙、磷、镁,血清甲状旁腺素（PTH）及血清骨源性碱性磷酸酶（BAP）。结果治疗后,D2组和D3组血清25羟D水平明显升高,差异有统计学意义（P〈0.01）;且治疗后D3组25羟D水平高于D2组,差异有统计学意义（P〈0.01）。治疗前后,2组血清磷、血清PTH均降低,差异有统计学意义（P〈0.01）,血清钙、血清镁、血清BAP无明显变化,差异无统计学意义（P〉0.05）。未出现维生素D中毒或药物相关不良反应表现。结论维生素D针剂无论是D2还是D3治疗维生素D缺乏或不足都是有效的,但在相同用法条件下D3比D2升高血清25羟D水平的幅度更大。维生素D注射剂30万U每2周1次共4次治疗维生素D不足或缺乏是安全的。Objective To compare the efficiency of vitamin D2 and vitamin D3 in raising the 25-hydroxyvitamin D（ 25（ OH） D） status of female healthy adults working indoor. Methods 94 healthy women coming from Chengdu City and who were in 40 - 55 years old were randomly divided into Group D2（ n =47,treated with vitamin D2 injection 7. 5mg every two weeks for four times） and Group D3（ n =47,treated with D3 injection as the same way）. The serum 25（ OH） D,parathyroid hormone（ PTH）,bone alkaline phosphatase（ BAP）,serum calcium and phosphorus were measured before and after the intervention. Results After treatment,the average 25（ OH） D level of Group D2、D3increased significantly,the difference was statistically significant（ P〈0. 01）. The 25（ OH） D level of Group D3 was higher than Group D2,the difference was statistically significant（ P〈0. 01）. The PTH and serum phosphorus of both groups decreased,the difference was statistically significant（ P〈0.01）. There were no significant change of serum calcium,BAP and serum magnesium（ P〈0.05）. There was no vitamin D intoxication or related adverse reactions after intervention. Conclusion vitamin D2 and vitamin D3 are both effect,but Vitamin D3 injection is more efficient than Vitamin D2 injection in raising the 25-hydroxyvitamin D status of female healthy adults with vitamin D deficiency. The method that vitamin D 3 injection 300000 U every two weeks for four times is safe.

关 键 词：血25羟维生素D 健康成年女性 维生素D2针剂 维生素D3注射液 维生素D缺乏 

分 类 号：R711[医药卫生—妇产科学]