Cosmc、T抗原和VEGFR/KDR在婴儿血管瘤不同分期的表达及意义  

Research on expression and significance of Cosmc,T antigen and VEGFR/KDR during different phases of infantile hemangiomas

作　　者：汤国雄[1] 李琴[1] 陶学金[1] 朱声荣[1] 周磊磊[1] 谢三祥[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院口腔医学中心,湖北武汉430030

出　　处：《临床口腔医学杂志》2014年第10期593-595,共3页Journal of Clinical Stomatology

基　　金：湖北省自然科学基金(2011CHB012)

摘　　要：目的:检测Cosmc、T抗原和VEGFR/KDR在婴儿血管瘤不同分期中表达的变化,探讨其在婴儿血管瘤病程发展演化中的意义。方法:采用免疫组织化学法检测Cosmc和T抗原和VEGFR/KDR在45例手术切除的婴儿血管瘤与10例正常皮肤组织的表达情况。所有标本经术后病理报告证实为婴儿血管瘤,根据Mulliken标准分为增生组、消退组和消退完成组。结果:1Cosmc、T抗原和VEGFR/KDR在增生组中高表达,阳性表达率明显高于消退组,统计结果具有显著性差异(P<0.05),且增生组与消退组的表达分别与对照组比较具有显著性差异(P<0.05)。2Cosmc在婴儿血管瘤中的表达与T抗原的表达呈显著正相关(r=0.50,P<0.01)。3VEGFR/KDR在婴儿血管瘤中的表达与T抗原的表达呈显著正相关(r=0.53,P<0.01)。结论:Cosmc、T抗原和VEGFR/KDR可能在婴儿血管瘤增生、消退过程中起关键作用。Objective：To investigate the expression of Cosmc,T antigen and VEGF R/KDRin different phases of in-fantile hemanginomas,and analyze the significance of the differerces. Method：Forty-five samples of infantile hemangioma tissue,excised in operation,and 10 normal controls were evaluated the expression of Cosmc,T antigen and VEGFR/KDR by immunohistochemistry. All thirty samples of infantile hemangioma, proved by pathologic method, were divided into pro-liferative and involuting groups, according to the Mulliken standard. Result：（1）Cosmc,T antigen and VEGFR/KDR showed an overexpression rate in proliferating infantile hemangiomas compared with involuting ones. The expression in the proliferative and involuting groups was significantly different （P ＆lt;0.05）,compared with the controls separately.（2）T antigen in IH showed positive correlation with Cosmc （r=0.50,P〈0.01）.（3）VEGFR/KDR in IH showed positive correlation with T antigen （r=0.53,P〈0.01）. Conclusion：Cosmc,T antigen and VEGFR/KDR may play key roles in the development of in-fantile hemangiomas,and a new theory for the development and prognosis of infantile hemangiomas may be provided.

关 键 词：婴儿血管瘤 T抗原 

分 类 号：Q786[生物学—分子生物学]