中医病证结合肝纤维化动物模型的研究概况  

Animal model of hepatic fibrosis showing combination of disease and syndrome

作　　者：彭岳[1,2] 苗维纳[1] 赵铁建[2] 段雪琳[2] 

机构地区：[1]成都中医药大学基础医学院生理学教研室,四川成都市610075 [2]广西中医药大学基础医学院生理学教研室,广西壮族自治区南宁市530200

出　　处：《世界华人消化杂志》2014年第27期4053-4059,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81160553;广西科学研究与技术开发计划基金资助项目;No.桂科攻13349005;广西研究生教育创新计划基金资助项目;No.JGY2014082~~

摘　　要：目前研究者制作的肝纤维化动物模型往往使用单一因素造模,模型虽然具备肝纤维化病理变化,却无气滞、气虚、肝郁、痰湿、血瘀等重要的中医证的特征.本文在总结了肝纤维化动物模型与病证结合动物模型研究概况后,评述了几种在中医病因学理论的指导下,运用复合多因素的造模方法建立的新型的病证结合疾病动物模型.这类肝纤维化模型动物同时具备疾病与证候双重特征,既复制出了符合中医证的基本特点,又与西医肝纤维化病理特征相一致.从而更准确地模拟了临床疾病与证候形成的病理机制及病变过程,为中西医结合研究肝纤维化疾病提供了新的研究平台及途径.Current animal models of liver fibrosis are of- ten developed using a single factor, and they have no traditional Chinese medicine （TCM） characteristics such as Qi stagnation, Qi defi- ciency, liver depression, phlegm, dampness and blood stasis, although they can show the pathological changes of hepatic fibrosis.In this paper, we initially give an overview of conventional animal models of hepatic fi- brosis, and then discuss new animal models of hepatic fibrosis showing combination of disease and syndrome that are developed us- ing multiple factors under the guidance of the etiology theory of TCM. These animal models have the double characteristics of the disease and syndrome and possess not only the basic characteristics in TCM but also the pathologic characteristics in Western medicine. They simulate the pathogenesis of clinical disease and syndrome more accurately, providing a new tool for studying liver fibrosis.

关 键 词：中医 病证结合 肝纤维化 动物模型 

分 类 号：R259[医药卫生—中西医结合] R-332[医药卫生—中医内科学]