甘精胰岛素对肝源性糖尿病血糖控制的疗效  

Efficacy of glargine in management of hepatogenic diabetes

作　　者：骆成林[1] 王少峰[2] 马春涛[1] 

机构地区：[1]苏州市相城人民医院消化科,江苏省苏州市215131 [2]苏州大学附属第二人民医院消化科,江苏省苏州市215004

出　　处：《世界华人消化杂志》2014年第27期4210-4213,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨甘精胰岛素在肝源性糖尿病中的应用价值.方法:应用甘精胰岛素控制82例肝源性糖尿病患者的血糖,随后对其空腹血糖(fasting b l o o d g l u c o s e,F B G)、餐后2 h血糖(2 h postprandial blood glucose,2 h PBG)及低血糖发生等情况进行随访24 wk,每12 wk检测一次糖化血红蛋白(glycosylated hemoglobin,HbAlc),然后将治疗12、24 wk后的FBG、2 h PBG及HbAlc与治疗前比较.结果:治疗12 wk后FBG、2 h PBG及HbAlc均较治疗前明显下降(FBG:6.35 mmol/L±1.47 mmol/L vs 10.52 mmol/L±3.13 mmol/L,P<0.05;2 h PBG:9.81 mmol/L±3.14 mmol/L vs17.51 mmol/L±4.33 mmol/L,P<0.05;HbAlc:7.54%±1.31%vs 10.65%±1.43%,P<0.05),而治疗24 wk后血糖及HbAlc与治疗12 wk后相比无明显变化(FBG:6.47 mmol/L±1.25 mmol/L vs 6.35 mmol/L±1.47 mmol/L,P>0.05;2h PBG:8.91 mmol/L±2.76 mmol/L vs 9.81mmol/L±3.14 mmol/L,P>0.05;HbAlc:7.28%±1.12%vs 7.54%±1.31%,P>0.05),治疗期间低血糖发生率低,仅仅发生过一次.结论:甘精胰岛素对肝源性糖尿病的血糖控制安全有效.AIM： To assess the efficacy of glargine in the management of hepatogenic diabetes.METHODS： Eighty-two patients with hepa- togenic diabetes treated with glargine were included in the study. The insulin dose was adjusted according to fasting blood glucose （FBG） till discharge. FBG, 2 h postprandial blood glucose （2 h PBG） and glycosylated hemoglobin （HbAlc） were monitored for 24 wk. HbAlc and blood glucose levels were compared before and after treatment.RESULTS： The FBG, 2 h PBG and HbAlc were significantly decreased after treatment （FBG： 6.35 mmol/L ± 1.47 mmol/L vs 10.52 mmol/L ± 3.13mmol/L, P 〈 0.05; 2 h PBG： 9.81 mmol/L ± 3.14 mmol/L vs 17.51 mmol/L ±4.33 mmol/L, P 〈 0.05; HbAlc： 7.54% ± 1.31% vs 10.65% ± 1.43%, P 〈 0.05）. There were no significant differences in the above parameters between 12 and 24 wk after treatment （FBG： 6.47 mmol/L ± 1.25 mmol/L vs 6.35 mmol/ L± 1.47 mmol/L, P 〉 0.05; 2 h PBG： 8.91 mmol/L ± 2.76 mmol/L vs 9.81 mmol/L ± 3.14 mmol/L, P 〉 0.05; HbAlc： 7.28% ±1.12% vs 7.54% ± 1.31%, P 〉 0.05）. The incidence of hypoglycemia was low, which occurred only once：CONCLUSION： Glargine therapy is effective and safe for hepatogenic diabetes.

关 键 词：甘精胰岛素 肝源性糖尿病 血糖 

分 类 号：R587.1[医药卫生—内分泌]