复方α-酮酸片对慢性维持性血液透析患者近期营养状况的影响  

Effects of Compound α-Keto Acid Tablets on Recent Nutritional Status in Chronic Hemodialysis Patients

作　　者：苏东东[1] 刘娜[1] 陈仁贵[1] 赵文琪[1] 叶婷[1] 周露[1] 车华[1] 郭赤 

机构地区：[1]广州军区武汉总医院血透室,武汉430070 [2]医学工程科

出　　处：《国际输血及血液学杂志》2014年第5期453-455,共3页International Journal of Blood Transfusion and Hematology

摘　　要：目的 探讨口服复方α-酮酸片对血液透析患者近期整体营养状况的影响.方法 选择2011-2012年,于广州军区武汉总医院接受慢性维持性血液透析治疗的60例患者为研究对象.根据入院号通过计算机随机分组方式将其分为研究组和对照组,每组各30例.对照组患者仅给予常规的蛋白质食物治疗,而研究组患者在常规治疗基础上加服复方α-酮酸片,剂量为630mg/片×4片×3次/d（本研究遵循的程序符合广州军区武汉总医院人体试验委员会所制定的伦理学标准,得到该伦理会批准,分组征得受试对象本人的知情同意,并与之签订临床研究知情同意书）.于治疗12周后,分析比较两组患者的人体测量学指标：体质量指数（BMI）、肱三头肌皮褶厚度、上臂肌围;以及主要血液生化指标：血红蛋白、血白蛋白、前白蛋白、三酰甘油及总胆固醇水平的变化.结果 治疗12周后,两组患者的BMI、肱三头肌皮褶厚度、上臂肌围3项人体测量学指标比较,差异无统计学差异（t=0.103,1.140,0.244;P＞0.05）;研究组患者的总胆固醇和三酰甘油水平分别为（4.42±1.02） mmol/L和（1.42±0.23） mmol/L,均低于对照组的（4.94±0.89）mmol/L和（4.63±1.01） mmol/L,两组比较,差异有统计学意义（t=2.10,2.36;P＜0.05）;研究组患者的血红蛋白、血白蛋白及前白蛋白水平分别为（98.15±3.12）g/L、（38.56±1.67）g/L和（336.34±20.12）mg/L,均高于对照组的（79.87±3.21）g/L、（35.23±1.32）g/L和（323.45±19.89）mg/L,两组比较,差异均有统计学意义（t=22.4,8.86,3.09;P＜0.05）.结论 复方α-酮酸片能显著改善慢性维持性血液透析患者近期营养状况,但其长期疗效仍待进一步观察.Objective To investigate the effects of compound α-keto acid tablets on recent nutritional status in chronic hemodialysis patients.Methods From 2011 to 2012,a total of 60 chronic hemodialysis patients who were treated in Wuhan General Hospita of Guangzhou Military Region were included in this study.According to these admission numbers,they were randomly divided into study group and control group by computer,with 30 cases in each group.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Wuhan General Hospital of Guangzhou Military Region.Informed consent was obtained from all participants.The patients in control group were treated by conventional protein foods,at the same time the study group were treated by compound α-keto acid tablets based on the treatment of control group,with 630 mg/table ＆#215; 4 tables＆#215; 3 times/d.Then investigated the anthropometry including body mass index （BMI）,skinfold thickness of triceps and arm muscle circumference,and main serum biochemicals indicators including hemoglobin,serum albumin,prealbumin,triglyceride and total cholesterol of the two groups after 12 weeks of treatment.Results After 12 weeks of treatment,there were no statistically significant differences between the two groups in anthropometry indicators of BMI,skinfold thickness of triceps,and arm muscle circumference （t=0.103,1.140,0.244;P〉0.05）.The levels of total cholesterol and triglyceride in study group were （4.42±1.02） mmol/L and （1.42±0.23） mmol/L,which were less than （4.94±0.89） mmol/L and （4.63±1.01） mmol/L in control group,respectively.There were statistically differences between the two groups in total cholesterol and triglyceride （t =2.10,2.36; P〈0.05）.The levels of hemoglobin,serum albumin and prealbumin in study group were （98.15 ±3.12） g/L,（38.56±1.67） g/L and （336.34±20.12） mg/L,which were higher than （79.87±3.21）g/L,（35.23± 1.32） g/L and （323.45 ± 19.89） mg/L in control group,respectively

关 键 词：生化指标 血液透析 复方Α-酮酸片 

分 类 号：R459.5[医药卫生—治疗学]