禁欲时间对精液参数及宫腔内人工授精妊娠率的影响  

Relationship of Sperm Parameters and Pregnancy Outcome after Intrauterine Insemination with Abstinence Period

作　　者：刘彩霞[1] 张仁礼[1] 韩冬[1] 蔡佳杰[1] 周艳[1] 张丽丽[1] 闻安民[1] 

机构地区：[1]广东省医学科学院//广东省人民医院生殖医学科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2014年第5期758-762,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省自然科学基金(9151008004000030);广东省医学科研基金(A2012028)

摘　　要：【目的】探讨禁欲时间对精液参数及宫腔内人工授精(IUI)妊娠率的影响。【方法】回顾性分析不育不孕患者共1 098个IUI治疗周期,检测记录每个周期的精液参数,包括精液体积、精子浓度、前向运动精子百分比(PR%)等;根据禁欲时间1(包括<24 h)、2、3、4、5、6、7 d分为7组,比较各组精液参数及妊娠率;女方患有子宫、输卵管、卵巢等病变的周期被排除后,共740个周期,比较各组妊娠率。【结果】随禁欲时间延长,精液体积、精子浓度、前向运动精子总数有上升趋势,前向运动精子百分比有下降趋势。1 098个IUI周期共获得147例临床妊娠,总周期妊娠率是13.4%。上述各组妊娠率依次为29%、15.6%、14.3%、13.7%、11.1%、8.8%和9.7%,妊娠率呈下降趋势,1组明显高于其他6组(P<0.05);排除女方病变后,获得101例临床妊娠,总妊娠率是13.6%,各组妊娠率依次为35%、18.2%、15.2%、15.1%、9.7%、8.1%、5.6%。【结论】尽管随禁欲时间延长,精液体积、精子密度和PR总数呈上升趋势,但IUI妊娠率呈下降趋势,禁欲1 d的夫妻显示IUI妊娠率最高。[Objective] To explore the relationship of sperm parameters and pregnancy outcome after intrauterine insemination （IUI） with abstinence period.[Methods] 1098 cycles of intrauterine insemination were retrospectively analyzed and the semen parameters were recorded for each insemination,including semen volume,sperm concentration and semen of progressive motility （PR％）.The patients were divided into 7 groups according to abstinence period.The sperm parameters and the pregnancy rates of every group were compared.Exclusion of women with lesions of uterus,ovary,oviduct and other diseases,740 cycles were analyzed and the pregnancy rates of every group were compared.[Results] Semen volume,sperm concentration and semen numbers of PR increased with duration of abstinence and semen of PR％ decreased.Pregnancy occurred in 147 cycles,resulting in an overall pregnancy rate per cycle of 13.4％.The pregnancy rate of every group were 29％,15.6％,14.3％,13.7％,11.1％,8.8％,and 9.7％,respectively.Exclusion of women with diseases,pregnancy occurred in 101 cycles,resulting in an overall pregnancy rate per cycle of 13.6％.The respective pregnancy rate of every group were 35％,18.2％,15.2％,15.1％,9.7％,8.1％,and 5.6％.The first one was significantly higher than other groups.[Conclusions] Though semen volume,sperm concentration and semen numbers of PR increased with duration of abstinence,the highest pregnancy rates were obtained in cases whose abstinence period was shorter.

关 键 词：禁欲时间 精液参数 宫腔内人工授精 妊娠率 

分 类 号：R698.2[医药卫生—泌尿科学] R711.6[医药卫生—外科学]