胰岛素提高糖尿病心肌病大鼠心肌组织的血管生成  

Improving angiogenesis in the myocardial tissue of diabetic cardiomyopathy by insulin treatment in rats

作　　者：陈力铨 桂春[1] 陈林林[1] 韦晓敏[1] 唐中立[1] 齐彬[1] 

机构地区：[1]广西医科大学第一附属医院心内科,南宁530021

出　　处：《中华内分泌代谢杂志》2014年第10期849-852,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81160021）

摘　　要：链脲佐菌素注射制备SD大鼠糖尿病模型,分为正常血糖对照组、糖尿病对照组、胰岛素治疗组.12周后,糖尿病组左心室压力上升最大速率和下降最大速率均明显降低（P＜0.05）,而胰岛素治疗组则较糖尿病组增高（P＜0.05）.糖尿病组心肌局部血流量明显低于对照组[（3.39±0.48对3.90±0.45）ml·g^-1·min^-1,p＜0.05],而胰岛素治疗组明显高于糖尿病组[（4.46±0.52对3.39±0.48）ml·g^-1·min^-1,P＜0.05].糖尿病组毛细血管密度比值低于对照组[0.429±0.091对0.545 ±0.082,P＜0.05],胰岛素治疗组则高于糖尿病组[0.494 ±0.076对0.429 ±0.091,P＜0.05].胰岛素治疗组的VEGF和Ang^-1表达较其他两组明显增多（P＜0.05）.提示胰岛素治疗可以提高糖尿病心肌病大鼠心肌组织的血管生成及增加局部心肌组织的血流量.Diabetic SD rats were established by injection of streptozotocin,and were divided into normal blood sugar control group（NC）,diabetic control group（DM）,and the insulin treatment group（IDM）.12 weeks later,the maximum rates of increasing and decreasing pressure in left ventricle were both decreased in DM group（P〈 0.05）,and those in IDM group were higher than those in DM group（P〈0.05）.Regional myocardial blood flow in DM group was lower than that in NC group [（3.39 ± 0.48 vs 3.90 ± 0.45） ml · g^-1 · min^-1,P〈 0.05],and that in IDM group was higher than that in DM group [（4.46 ± 0.52 vs 3.39 ± 0.48） ml · g^-1 · min^-1,P〈0.05].The capillary density ratio in DM group was lower than that of NC group [0.429 ± 0.091 vs 0.545 ± 0.082,P〈0.05],but that in IDM group was higher than DM group [0.494 ± 0.076 vs 0.429 ± 0.091,P〈0.05].VEGF and Ang^-1 expression in DM group were the highest in 3 groups （P〈0.05）.Insulin therapy may improve the angiogenesis and myocardial blood flow in diabetic rats with cardiomyopathy.

关 键 词：血管生成 胰岛素 糖尿病心肌病 中子活化同位素微球 心肌血流量 

分 类 号：R587.2[医药卫生—内分泌]