骨钙素的能量代谢调节作用  

Regulation of energy metabolism by osteocalcin

作　　者：盛彤[1] 郭翔宇[1] 王新祥[1] 谢培凤[1] 商学征[1] 周晖[1] 关菘[1] 龚雁冰[1] 王颖[1] 

机构地区：[1]北京中医药大学东方医院内分泌代谢科,100078

出　　处：《中华内分泌代谢杂志》2014年第10期862-864,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（30873290）

摘　　要：成骨细胞分泌的骨钙素是反映成骨细胞活性的敏感而特异的指标.近年的研究还发现,骨钙素是骨骼内分泌功能的重要媒介.羧化不全骨钙素可以促进胰岛β细胞增殖和胰岛素分泌,降低血糖和血脂水平,表明骨钙素对能量代谢具有重要的调控作用,这一发现将为肥胖症和糖尿病等代谢性疾病的治疗提供新的思路.Osteocalcin （OC） secreted by osteoblasts is a sensitive and specific indicator of osteoblast activity.Recently,it has been found that osteocalcin serves as an important mediator of endocrine function.Undercarboxylated OC can promote insulin secretion and β-cell proliferation,and lower glucose and lipid levels,suggesting that osteocalcin might play a major role in the regulation of energy metabolism.These findings provide a new insight for the treatment of metabolic diseases such as obesity and diabetes.

关 键 词：骨钙素 成骨细胞 肥胖症 

分 类 号：R589.2[医药卫生—内分泌] R587.1[医药卫生—内科学]