中国生物化学基础研究40年回顾  

A Recollection of Forty Years of Biochemistry Research in China

作　　者：林其谁[1] 

机构地区：[1]中国科学院上海生命科学研究院生物化学与细胞生物学研究所,上海200031

出　　处：《生物化学与生物物理进展》2014年第10期930-935,共6页Progress In Biochemistry and Biophysics

摘　　要：《生物化学与生物物理进展》创刊的40年中,特别是改革开放后,我国生物化学研究得到了巨大的进步,许多方面在国际生物化学界有了一席之地,有的曾处于国际领先地位.除本专刊有专文论述的酶学、生物膜、结构生物学外,本文主要介绍:人工全合成酵母丙氨酸转移核糖核酸(tRNAAla);乙肝病毒adr亚型的全基因组克隆和研究;人类、水稻和一些生物基因组研究;功能基因组研究及一些与疾病或水稻性状密切有关的基因的发现;植物分子育种方法的创立;动植物与酵母的重要基因的表达调控研究取得的突出成绩;在RNA研究,包括tRNA、SnoRNA,核酶等方面新的突破;在多肽、蛋白质、蛋白质组、糖复合物等方面取得的成绩.In the past 40 years, since the publication of Progress in Biochemistry and Biophysics, especially after carry out the reform and opening policies, biochemistry research in China has been achieved great successes. Quite number aspects had their position in international biochemical research; some had been at the leading position. Beside enzymology, biological membranes and structure biology, they have their own paper for introduction in this issue, the present paper describe progresses mainly on total synthesis of yeast alanine transfer RNA; cloning and study on hepatitis B virus adr subtype; genome study on human genome, rice genome and some other genomes; functional genomics study found certain oncogene or disease related gene, as well as rice genes which correspond to relative trait; developed technology for molecular breeding in plants; important results were obtained on gene expression and regulation in animals, plants and yeast; new break through were obtained in RNA research, which include tRNA, SnoRNA, and ribozyme; good results also had been obtained in research on peptide, protein, proteomics and glucoconjugates.

关 键 词：生物化学 基因组学 RNA 

分 类 号：Q5[生物学—生物化学]