急性冠状动脉综合征患者血清sLox-1和hsCRP检测的意义  

Significance of detecting serum soluble lectin-like oxidized low density lipoprotein receptor-l and high-sensitivity C-reactive protein in patients with acute coronary syndrome

作　　者：焦云根[1,2] 刘乃丰[1] 孙晓宁[2] 张振刚[2] 

机构地区：[1]东南大学医学院,江苏省210000 [2]扬州市第一人民医院心血管病科

出　　处：《江苏医药》2014年第20期2434-2437,共4页Jiangsu Medical Journal

摘　　要：目的探讨检测急性冠状动脉综合征(ACS)患者血清水溶性凝集素样氧化低密度脂蛋白受体1(sLox-1)和超敏C反应蛋白(hsCRP)的意义。方法采用酶联免疫吸附法测定34例ACS患者(A组)、28例稳定型心绞痛(SAP)患者(B组)和27例非冠心病患者(C组)的血清sLox-1和hsCRP水平。结果 A组血清sLox-1和hsCRP水平高于B、C组[(243.20±47.34)ng/L vs.(206.67±52.30)ng/L、(170.45±46.78)ng/L和(11.53±2.19)mg/L vs.(5.68±1.47)mg/L、(3.43±1.25)mg/L](P<0.05或P<0.01);B组血清sLox-1和hsCRP水平高于C组(P<0.05)。ACS患者血清hsCRP与sLox-1的水平呈正相关(r=0.927,P<0.01)。结论 ACS患者血清sLox-1和hsCRP水平明显升高;二者均可作为反映动脉粥样硬化斑块不稳定的血清学指标。Objective To investigate the significance of detecting serum soluble lectin-like oxidized low-density lipoprotein receptor-1 （sLox-1） and high-sensitivity C-reactive protein（hsCRP） in the patients with acute coronary syndrome（ACS）. Methods Enzyme-linked immunosorbent assay was used to measure serum levels of sLox-1 and hsCRP in 34 ACS patients（group A）, 28 patients with stable angina pectoris （group B） and 27 patients without coronary heart disease （group C）. Results Serum levels of sLox-1 and hsCRP were higher in group A than those in groups of B and C[（243.20±47.34） ng/L vs. （206.67±52.30） ng/L and （170.45±46.78） rig/L, and （11.53±2.19） mg/L vs. （5.68±1. 47） mg/L and （3.43±1.25） mg/L]（P〈0. 05 or P〈0. 01） ,which were higher in group B than those in group C（P〈0. 05）. Serum level of sLox-1 was positively correlated with that of hsCRP in ACS patients（r=0. 927,P〈0. 01）. Conclusion Serum levels of sLox-1 and hsCRP are elevated in ACS patients,which may be taken as potential serum markers of plaque instability.

关 键 词：凝集素样氧化低密度脂蛋白受体1 超敏C反应蛋白 急性冠状动脉综合征 

分 类 号：R541[医药卫生—心血管疾病]