三维与二维斑点追踪技术评价急性心肌梗死犬左心室局部收缩功能的实验研究  

Experimental study of evaluating left ventricular regional systolic function using speckle tracking echocardiography in acute myocardial infarction model of dogs： comparison of three-dimensional and two-dimensional approaches

作　　者：张瑞芳[1] 宋歌[1] 刘会若[1] 武丽娜[1] 郭玮涛 霍婷婷[1] 郭海燕[1] 

机构地区：[1]郑州大学第一附属医院超声科,450052

出　　处：《中华超声影像学杂志》2014年第10期902-906,共5页Chinese Journal of Ultrasonography

基　　金：国家自然科学基金项目（U1204822）

摘　　要：目的 探讨三维斑点追踪显像（3D-STI技术）评价急性心肌梗死犬左室局部收缩功能的应用价值.方法 对24只成年比格犬左冠状动脉前降支（LAD）结扎前、结扎180 min后分别行二维斑点追踪显像（2DD-STI）及3D-STI检查.实验结束后,行心肌氯化三苯基四氮唑（TTC）染色,确定梗死心肌节段和非梗死心肌节段,比较两者间纵向收缩期峰值应变（LS）的大小及运用2D-STI和3D-STI的耗时.结果 20只犬成功建立急性心肌梗死模型.结扎后梗死心肌节段2D-STI和3D-STI的LS均较结扎前的基础状态明显减低（P＜0.01）,运用3D-STI存储和分析图像所用时间明显短于2D-STI（P＜0.01）.3D-STI参数的ROC曲线下面积比2D-STI大.以3D-STI的LS值-12.56％为截点诊断急性心肌梗死的敏感性77.9％,特异性88.2％.结论 3D-STI可准确评价节段性室壁运动异常,是一种方便、准确的评价急性心肌梗死的新方法.Objective To investigate the value of three-dimensional speckle tracking imaging（3D-STI） in assessment of left ventricular regional systolic function in acute myocardial infarction model of dogs.Methods Left anterior descending （LAD） coronary artery was ligated in 24 adult beagle dogs.Longitudinal strain（LS） of every left ventricular segment before ligation and 180 min after ligation,and the time for acquisition and analysis were obtained using two-dimensional speckle tracking imaging （2D-STI） and 3D-STI.After the experiment,left ventricular myocardium were determined by TTC staining and divided into two groups：infarcted myocardial segments and non-infarcted myocardial segments.Results Experimental model of acute myocardial infarction was established successfully in 20 dogs.After ligation,both LS of 2D-STI and 3D-STI in infarcted myocardial segments were significantly lower （P 〈 0.01）.The time for acquisition and analysis of the images by 3D-STI were significantly shorter than that by 2D-STI （P 〈0.01）.The area under the ROC curve of 3D-STI was larger than that of 2D-STI.A cut-off value of-12.56% for LS of the 3D-STI had 77.9% sensitivity and 88.2% specificity in predicting acute myocardial infarction.Conclusions 3D-STI is a convenient,accurate method for evaluating left ventricular regional systolic function.

关 键 词：超声心动描记术 心肌梗死 心室功能 左 斑点追踪显像 

分 类 号：R542.22[医药卫生—心血管疾病]