硫化氢对阿尔采末病保护作用的研究进展  

Progress in research on protective effects of hydrogen sulfide on Alzheimer disease

作　　者：刘慧宇[1] 邓媛媛[1] 刘远贵 龚其海[1] 

机构地区：[1]遵义医学院药理学教研室暨贵州省基础药理重点实验室,贵州遵义563000

出　　处：《中国新药与临床杂志》2014年第10期707-712,共6页Chinese Journal of New Drugs and Clinical Remedies

基　　金：国家自然科学基金(81360489);教育部创新团队(IRT1197);贵州省科教青年英才培养工程项目([2012]170)

摘　　要：阿尔采末病是一种神经退行性疾病,在老年人疾病谱中的地位日益突出,其发病机制未完全明了,无理想的治疗药物。新近研究证实,硫化氢具有抗氧化、抗凋亡、抗炎作用,在阿尔采末病的发生、发展过程中扮演重要角色。本文综述了硫化氢的生物学特点及作用,特别强调了硫化氢在阿尔采末病病理生理学中的保护作用,旨在为后续研究该病的治疗药物提供新思路。Alzheimer disease （AD） is a neurodegenerative disease and stands increasingly prominent position in the disease spectrum of the elderly. Its pathogenesis drugs are unavailable yet. Recent studies clearly indicate that hy apoptotic, and anti-inflammatory effects and plays an important This review summarizes biological characters and actions of H2S, is still fully unknown and the ideal treatment drogen sulfide （H2S） exerts antioxidant, anti- role in the occurrence and development of AD. especially highlights the actions of H2S on AD pathophysiology, in order to provide a new strategy for subsequent AD therapy.

关 键 词：阿尔茨海默病 硫化氢 氧化性应激 细胞凋亡 炎症 

分 类 号：R971[医药卫生—药品]