复方樟柳碱治疗糖尿病性视网膜病变的疗效观察  

Curative effect observation of compound anisodine hydrobromide in the treatment of diabetic retinopathy

作　　者：何芳邻[1] 陆琳娜[1] 车欣[1] 徐晓芳[1] 朱东青 范先群[1] 王志良[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院眼科,200011

出　　处：《中国实用医药》2014年第29期22-24,共3页China Practical Medicine

摘　　要：目的观察复方樟柳碱穴位注射治疗糖尿病性视网膜病变的临床疗效。方法本研究是前瞻性的对照研究,入选糖尿病性视网膜病变(diabetic retinopathy,DR)Ⅱ期的患者80例80眼,其中治疗组50例50眼,对照组30例30眼。治疗组患者给予复方樟柳碱注射液2 ml作患侧眼的颞浅动脉旁皮下注射,1次/d,共计注射20 d。用药前及用药后30 d分别行Snellen视力表最佳矫正视力(best corrected visual acuity,BCVA)、视网膜振荡电位(oscillatory potenlials,OPS)及对比敏感度(contrastsen sitivity,CS)检查。对照组患者亦给予间隔30 d的上述相同检查。结果 DRⅡ期治疗组患者用药后BCVA有轻度的提高[(0.50±0.16 VS 0.52±0.15),P<0.05]。治疗组患者用药前OPS总振幅(96.7±29.4)μV,用药后(119.5±32.8)μV,差异有统计学意义(P<0.01)。治疗组患者用药后CS检查在低频(1.5 c/d、3.0 c/d)、中频(6.0 c/d)和高频(12.0 c/d、18.0 c/d)均有显著的提高(P<0.01)。对照组患者的BCVA、OPS、CS在30 d内差异无统计学意义(P>0.05)。结论复方樟柳碱穴位注射可显著改善DRⅡ期患者的视网膜血液供应,改善患者的视觉质量,值得在DR患者中早期临床应用。Objective To observe the clinical effect of compound anisodine hydrobromide through acupoint injection therapy in the treatment of diabetic retinopathy. Methods This was a prospective control study of 80 cases of patients （80 eyes） with diabetic retinopathy （DR） H period. There were 50 cases （50 eyes） in the treatment group and 30 cases （30 eyes） in the control group. The treatment group was treated by compound anisodine injection 2 ml for superficial temporal artery of the ipsilateral eye next to the subcutaneous injection once a day, and for a total injection of 20 d. The snellen chart of best corrected visual acuity （BCVA）, retinal oscillatory potentials （OPS） and contrast sensitivity （CS） were performed in preoperative and postoperative 30 d respectively. All control group patients were also given the same examinations interval of 30 d. Results The treatment group of DR Ⅱ had a slight increase of BCVA [ （0.50 ± 0.16 VS 0.52 ± 0.15）, P〈0.05 ] . OPS total amplitude of the patients treated with compound anisodine hydrobromide was （96.7 ± 29.4） μV before drug application, and was （119.5 ± 32.8） μV after drug application. The differences were statistically significant （P〈0.01）. Postoperative CS check of treatment group in the low-frequency （1.5 c/d, 3.0 c/d）, middle frequency （6.0 c/d） and high fIequency （12.0 c/d, 18.0 c/d） were all significantly improved （P〈0.01）. The control group had no significant differences in BCVA, OPS and CS examines within 30 d （P〉0.05）. Conclusions The compound anisodine hydrobromide through acupoint injection can significantly improve the retinal blood supply and visual quality of the DR II patients. It is worthy of applying in patients of DR in the early period.

关 键 词：复方樟柳碱 糖尿病性视网膜病变 视网膜振荡电位 对比敏感度 

分 类 号：R587.2[医药卫生—内分泌]