2-对氟苯基-5-羟基嘧啶的合成及表征  

Synthesis and Characterization of 2-(4-fluorophenyl)-5-hydroxy-pyrimidine

作　　者：周小锋[1] 蔡国强[2] 

机构地区：[1]杭州职业技术学院,浙江杭州310018 [2]浙江大学化学系,浙江杭州310018

出　　处：《山西大学学报（自然科学版）》2014年第4期620-624,共5页Journal of Shanxi University(Natural Science Edition)

基　　金：杭州市绿色精细化工研究与技术转化重点实验室资助项目(HZJ2012-10)

摘　　要：研究了一种以2,4-二氯-5-甲氧基嘧啶为起始原料,经选择性脱氯、Suzuki偶联及脱甲基三步反应合成有机医药中间体2-对氟苯基-5-羟基嘧啶的工艺,总收率达60%。分析探讨了反应机理和影响因素,产品结构经1 H NMR表征确认。This paper studied a technology,which takes 2,4-dichloro-5-oxo-methylpyrimidine as starting materials and synthesizes an important organic pharmaceutical intermediate 2-（4-fluorophenyl）-5-hydroxy-pyrimidine in three steps including selective hydrodechlorination,Suzuki coupling and demethylation,with total yield of 60%.The reaction mechanism and influence factors were discussed,and the structures of the compounds were confirmed by 1H NMR.

关 键 词：2-对氟苯基-5-羟基嘧啶 嘧啶 SUZUKI偶联 

分 类 号：O626.41[理学—有机化学]