防止固体分散体老化的研究进展  

Research progress of preventing solid dispersion′s aging

作　　者：王文月[1,2] 陈菊明[1,2] 庄珊珊[1,2] 宋洪涛[1] 

机构地区：[1]南京军区福州总医院药学科,福建福州350025 [2]福建医科大学药学院,福建福州350108

出　　处：《中国医院药学杂志》2014年第21期1858-1861,共4页Chinese Journal of Hospital Pharmacy

基　　金：福建省科技计重点项目(编号:2007Y0063)

摘　　要：将难溶性药物制成固体分散体是提高其溶解度和溶出率的最具应用潜力的方法之一,但由于固体分散体存在着许多缺点,制约工业化发展,特别是老化的问题。本文综述影响固体分散体老化的因素以及防止的方法。Solid dispersion is one of the most potential applications which are used to improve the solubility and dissolution rate of the poorly soluble drug. But the shortcomings of the solid dispersion, especially the problem of aging, restrict the development of solid dispersion industrialized. The factors affecting the aging of the solid dispersion and the methods of preventing it are discussed.

关 键 词：固体分散体 稳定性 老化 

分 类 号：R94[医药卫生—药剂学]