正交试验优选暑热宁口服液挥发性活性物质的提取工艺  

Optimization of the Extraction Technology of Volatile Active Substance from Shurening Oral Liquid by Orthogonal Test

作　　者：李凤丽[1,2] 李进[1] 高文远[3] 陈涛[1] 王进博[1] 

机构地区：[1]天津中医药大学第一附属医院,天津300193 [2]天津中医药大学研究生部,天津300193 [3]天津大学生命科学院,天津300193

出　　处：《中国药房》2014年第43期4059-4062,共4页China Pharmacy

基　　金：国家科技重大专项课题(No.2010ZX09102-201)

摘　　要：目的：优选暑热宁口服液挥发性活性物质提取工艺。方法：以麝香草酚与香荆芥酚含量为考察指标,以蒸馏液体积倍数、浸泡时间、蒸馏速度为考察因素,通过单因素考察与正交试验优选暑热宁口服液挥发性活性物质提取工艺。结果：优选工艺为1.5倍提取蒸馏液浸泡12 h,蒸馏速度30~40滴/min。结论：优选的工艺合理、可行,可为工业化生产提供参考。OBJECTIVE： To optimize the extraction technology of volatile active substance from Shurening oral liquid. METH- ODS： The extraction technology of volatile active substance from Shurening oral liquid was optimized by single factor and orthogo- nal design with the volume of distilland, distillation time and distillation speed as factors using the contents of tnymol and carvacrol as index. RESULTS： The optimized technology was as follows： 1.5 times distilland, soaking for 12 h and distillation speed of 30-40 drops/min. CONCLUSIONS： The optimized technology is reasonable and feasible, and can provide reference for industrial production.

关 键 词：暑热宁口服液 气相色谱法 麝香草酚 香荆芥酚 正交试验 提取工艺 

分 类 号：R97[医药卫生—药品]