正常踝-臂指数体检人群与传统动脉硬化性疾病危险因素的相关及线性回归分析  

Correlation and Multiple Linear Regression Analysis of Arteriosclerosis Related Factors in Healthy Screening Population with Normal Anklebrachial Index

作　　者：吴建中[1] 李晓利[2] 王强[3] 赵华[1] 王勇[1] 张金萍[4] 李秦[2] 廖庆林[1] 

机构地区：[1]解放军第309医院旃坛寺门诊部,北京100034 [2]解放军第309医院干部病房,北京100091 [3]解放军第309医院移植中心,北京100091 [4]解放军第305医院干部病房,北京100034

出　　处：《医学研究杂志》2014年第10期33-36,共4页Journal of Medical Research

基　　金：国家自然科学基金资助项目(8130025)

摘　　要：目的 踝-臂指数（ankle-brachial index,ABI）是评价外周动脉硬化的无创检测技术,本研究旨在探讨ABI正常体检人群与传统动脉硬化性疾病危险因素之间的关联性.方法 入选2011年10月～2012年12月解放军第309医院体检中心,ABI为0.9 ～1.3的体检人群,共643例,纳入年龄、性别、心率、体重指数、腰围、高血压病史、糖尿病史、吸烟史、饮酒史、总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、尿酸和空腹血糖等动脉硬化疾病相关危险因素,采用单变量相关分析和多元线性回归方法,分析上述因素与ABI关联性.结果 单因素相关分析发现心率与ABI呈负相关（P=0.05）,年龄和血糖与ABI呈正相关（P ＜0.001,P=0.01）.进一步行回归分析发现慢心率、增龄和糖尿病是高ABI的决定因素（P＜ 0.001）,有统计学意义.结论 增龄、高血糖、糖尿病是ABI增高主要的危险因素,因此在高龄、空腹血糖调节受损、糖尿病人群中,开展ABI检查对于动脉硬化的筛查具有针对性.Objective To study correlation of conventional risk factors for atherosclerotic disease with ankle - brachial index （ABI） in the normal range. Methods Totally 643 healthy screening participants whose ABI were from 0.9 to 1.3 from Oct 2011 to Dec 2012 in PLA 309 Hospital were selected. ABI was dependent factor, and age, gender, heart rate, body mass index, waist circumference, hyper- tension, diabetes, smoking history, drinking history, total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein and fasting plasma glucose were independent factors. Univariate correlation and multiple linear regressions were used to analyze the correlation of the above factors with ABI. Results Univariate analysis showed that ABI was inversely correlated with heart rate ABI （P = 0.05 ） , and ABI was positively correlated with age （ P 〈 0. 001 ） and fasting plasma glucose （ P = 0.01 ）. Further multiple linear regressions analy- sis revealed that lower heart rate, aging and diabetes were independent determinants of increased ABI （ P 〈 0. 001 ）. Conclusion Aging, high fasting glucose and history of diabetes are the major risk factors for elevated ABI, which suggestes that it is essential for ABI measurement in the elderly and population with impaired fasting glucose or diabetic history.

关 键 词：踝-臂指数 动脉硬化 危险因素 

分 类 号：R543[医药卫生—心血管疾病]