抗纤维化药物在预防尿道狭窄复发中的应用和研究进展  

Application and research progress of anti-fibrosis drug in preventing recurrent urethra stricture

作　　者：张楷乐[1] 张羽萌[1] 王营[1] 傅强[1] 陈嵘[1] 

机构地区：[1]上海交通大学附属第六人民医院泌尿外科,上海200233

出　　处：《临床泌尿外科杂志》2014年第11期1030-1034,共5页Journal of Clinical Urology

基　　金：上海市科委基础研究领域项目(编号14JC1492100)

摘　　要：尿道狭窄是常见的男性下尿路疾病,该疾病的治疗难点在于其相当高的手术后狭窄复发率,因此如何防止尿道狭窄术后的复发,已成为下尿路重建外科领域的研究重点。除了注意常规的手术操作要点外,适当的药物运用也是防止尿道狭窄复发的常见方法。本文归纳总结了已有的各种药物在预防尿道狭窄复发中的研究报道,探索效果最佳的药物并反思现有研究的不足。Urethral stricture is a common lower urinary tract disease in men.The difficulty in treatment of this disease is the fairly high recurrence rate postoperatively,and therefore how to prevent recurrence of urethral stricture has become a focus in urinary tract reconstruction surgery research field.In addition to paying attention to operation key points,the appropriate use of drugs to prevent urethral stricture is also a common way.This review has summarized the existing drugs for preventing recurrence of urethral stricture reported clinically and basic research of exploring the most efficient anti-fibrosis drugs,and has thought about the drawbacks of existing research

关 键 词：抗纤维化药物 尿道狭窄 复发 激素 

分 类 号：R693.2[医药卫生—泌尿科学]