破骨细胞形成和功能调节的研究进展  

RESEARCH PROGRESS OF REGULATION OF OSTEOCLAST FORMATION AND FUNCTION

作　　者：颜艳[1,2] 林欣[1,2] 代晓华[1,2] 王冠华[1,2] 张林朴[1,2] 邹慧儒[1,2] 

机构地区：[1]南开大学口腔医院 [2]天津市口腔医院中心实验室,天津300041

出　　处：《中国修复重建外科杂志》2014年第11期1435-1440,共6页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的综述破骨细胞(osteoclast,OC)的形成和功能调节机制的研究进展。方法查阅近年OC形成、活化调节机制和发挥功能的相关文献,并进行总结分析。结果巨噬细胞集落刺激因子和NF-κB受体活化因子配基是OC形成和功能调节全过程中重要的两种细胞因子;除了参与骨吸收,OC还具有参与免疫应答、调节成骨细胞形成等功能。结论对OC形成和功能调节的研究进一步揭示了各种骨性疾病对骨组织的破坏机制,有助于临床寻找更合适的生物学治疗靶标。Objective To review the recent research progress of the regulatory mechanisms of osteoclast （OC） formation and functions. Methods The related literature on OC formation, activation, and functions was reviewed, analyzed,and summarized. Results Macrophage colony stimulating factor and receptor activator of nuclear factor-κB ligand are essential cytokines which regulate all aspects of OC formation and functions. In additional to mediating bone resorption, OCs also participate in regulation of osteoblast formation and immune responses. Conclusion The researches on the regulation of OC formation and functions have further revealed the destruction mechanisms of various kinds of bone diseases, which will facilitate to find more suitable biological targets for clinical therapy.

关 键 词：破骨细胞 成骨细胞 骨重建 细胞因子 趋化因子 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]