在心肌组织工程构建中的心肌干细胞:认识现状与预测未来  

Cardiac stem cells in cardiac tissue engineering: present and future

作　　者：李润琴[1] 黄春[1] 

机构地区：[1]重庆三峡医药高等专科学校,重庆市404120

出　　处：《中国组织工程研究》2014年第37期6064-6068,共5页Chinese Journal of Tissue Engineering Research

基　　金：重庆教委科学技术研究项目(KJ101804)~~

摘　　要：背景:长期以来,人们认为成年哺乳动物的心肌是终末分化的组织,没有再生能力。心肌细胞一旦受损将由纤维结缔组织取代。目的:重新认识心肌细胞,对心肌干细胞的相关研究做一综述,以明确心肌干细胞的存在。方法:计算机检索中国期刊网全文数据库以及PubMed数据库2003至2014年期间有关心肌干细胞的文章。检索词分别为"心肌干细胞,干细胞,心脏再生"和"cardiac stem cells,stem cells,cardiac regeneration"。初检得到82篇文献,最终纳入文章40篇。结果与结论:心脏中存在具有再生潜能的心肌干细胞,现已研究出一些心肌干细胞的表面标记物。心肌干细胞的研究为临床治疗某些心肌细胞损伤性疾病开辟了崭新的思路,但心肌干细胞的数量较少,如何分离纯化、培养鉴定,并扩增为满足再生医学和组织工程需要的心肌细胞还有待于进一步研究,心肌干细胞的研究将为心肌组织工程研究开辟崭新的途径。BACKGROUND：For a long time, the myocardium of adult mammalians is the terminal y differentiated tissue with no regeneration capacity. If damaged, myocardial cells wil be replaced by fibrous connective tissue. OBJECTIVE：To rediscover the myocardial cells and to do a review for cardiac stem cells, in order to define the existence of myocardial cells. METHODS：A computer-based online research of CNKI and PubMed databases was performed to col ect articles published between 2003 and 2014 with the key words of“cardiac stem cells, stem cells, cardiac regeneration”in Chinese and English, respectively. There were 82 articles after the initial survey, and final y 40 articles were included in result analysis. RESULTS AND CONCLUSION：Cardiac stem cells exist in the heart, and some surface markers of cardiac stem cells have been discovered. Cardiac stem cells for some diseases with myocardial cellinjury have opened up a new way. Because of the smal number of myocardial cells, how to purification, culture, identification and proliferation wil be further studied to meet the need for regenerative medicine and tissue engineering. Cardiac stem cellresearch wil open a new approach for cardiac tissue engineering.

关 键 词：干细胞 移植 心肌干细胞 心脏再生 综述 

分 类 号：R318[医药卫生—生物医学工程]