神经肌肉电刺激治疗膝骨关节炎疼痛的Meta分析  

Efficacy of neuromuscular electrical stimulation on pain of patients with knee osteoarthritis: a meta-analysis

作　　者：谢东兴 王伊伦 李辉[1] 杨拓[1] 邓桢翰[1] 杨烨[1] 张屹[1] 丁翔[1] 雷光华[1] 

机构地区：[1]中南大学湘雅医院骨科,湖南省长沙市410008

出　　处：《中国组织工程研究》2014年第38期6228-6232,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(81272034);湖南省发改委项目([2013]1199);湖南省科技厅科研项目(2013SK2018);教育部博士点基金(20120162110036)~~

摘　　要：背景:膝关节骨关节炎早、中期的治疗方法以对症治疗为主,有研究表明神经肌肉电刺激用于膝关节骨关节炎的治疗能改善患者的疼痛评分,但目前对于其疗效仍存在争议。目的:评价神经肌肉电刺激治疗膝关节骨关节炎患者疼痛的疗效。方法:计算机检索Medline数据库和手工查找神经肌肉电刺激治疗膝关节骨关节炎相关文献的全文,所有检索截止至2014年7月3日。搜集国内外研究神经肌肉电刺激对膝关节骨关节炎患者疼痛评分影响的随机对照试验,2名研究人员独立按照纳入和排除标准筛选文献,采用Cochrane协作网提供的Revman 5.2软件进行Meta分析。结果与结论:共纳入5项随机对照试验,累计239例研究对象。Meta分析结果显示,与空白对照组相比,神经肌肉电刺激对减轻膝关节骨关节炎患者的疼痛无统计学意义[均数差=-0.40,95%置信区间(-1.34-0.54),P=0.40]。结果表明,神经肌肉电刺激对改善膝关节骨关节炎患者的疼痛情况无明显疗效。但由于纳入的样本量较小,参数选择存在较大的差异,所以未来尚需大样本和高质量的随机对照试验对结果做进一步的证实。BACKGROUND： Symptomatic treatment is the main management strategy for patients with knee osteoarthritis at early metaphase. Some previous studies have demonstrated that neuromuscular electrical stimulation can alleviate pain in knee osteoarthritis patients. To date, this effectiveness, however, still remains controversial. OBJECTIVE： To assess the efficacy of neuromuscular electrical stimulation on pain in patients with knee osteoarthritis. METHODS： Randomized controlled trials concerning the efficacy of neuromuscular electrical stimulation in the treatment of knee osteoarthritis were identified from the Medline database conducted up to July 3, 2014. These studies were selected independently by two reviewers according to the inclusion and exclusion criteria. Meta-analysis was performed using Revman5.2 software. RESULTS AND CONCLUSION： A total of 5 randomized controlled trials consisting of 239 participants were included. The results of the meta-analysis indicate neuromuscular electrical stimulation has no significant impact on measure of pain in knee osteoarthritis patients in comparison to the blank control group [mean difference= -0.40, 95% confidence interval （-1.34-0.54）, P=0.40]. Owing to the sample limitations of our study, it is hard for us to draw a conclusion that the application of neuromuscular electrical stimulation in managing pain in patients with knee osteoarthritis is of little significance. Further work based on large-sample and high-quality randomized controlled trials is needed to determine the role of neuromuscular electrical stimulation in pain in this population.

关 键 词：骨关节炎 膝关节 疼痛 经皮神经电刺激 组织构建 骨组织工程 物理疗法 神经肌肉电刺激 系统评价 META分析 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]