强效镇痛药羟考酮复方的研究进展  

Advancement of potent narcotic analgesics:combination of oxycodone

作　　者：董国明 

机构地区：[1]北京华素制药股份有限公司,北京100081

出　　处：《中国药理学与毒理学杂志》2014年第5期758-764,共7页Chinese Journal of Pharmacology and Toxicology

摘　　要：阿片受体激动剂羟考酮是强效麻醉性镇痛药,其镇痛作用强,但其耐受性、依赖性及其抑制胃肠道平滑肌蠕动等不良反应限制了其临床应用。自20世纪末,研究者开始分别将解热镇痛药、阿片受体激动剂、阿片受体拮抗剂、多巴胺受体拮抗剂等药物与羟考酮以不同比例进行组方,在增强镇痛作用的同时能降低羟考酮的用量并减少其不良反应,从而达到限制其滥用的目的。本文仅就羟考酮复方的发展进行较为系统的综述,以期为进一步促进其临床应用提供依据。Oxycodone,an opioid receptor agonist,is one of potent narcotic analgesics. Despite its potent analgesic effect,the tolerant and dependent liability of oxycodone as well as its inhibition on gas-trointestinal motility strongly restricts its clinical application. Since the end of the last century,antipyretic, opioid receptor agonist,opioid receptor antagonist and dopamine receptor antagonist have been used to in combination with oxycodone at different ratios as complex prescriptions,the aim of which is to enhance the effect of oxycodone,decrease the dosage of oxycodone,and prevent the adverse effect and the tendency for misuse. Here we reviewed the development of oxycodone compositions in the recent years,hoping to provide more data for its potential clinical application.

关 键 词：羟考酮 镇痛药 非麻醉 受体拮抗剂 阿片 受体激动剂 阿片 罗通定 

分 类 号：R971.1[医药卫生—药品]