量子点的神经毒性效应研究进展  

Research advance in neurotoxicity of quantum dots

作　　者：吴添舒[1] 唐萌[1] 

机构地区：[1]东南大学公共卫生学院环境医学工程教育部重点实验室,江苏省生物材料与器件重点实验室,江苏南京210009

出　　处：《中国药理学与毒理学杂志》2014年第5期794-800,共7页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(30671782);国家自然科学基金(30972504);国家自然科学基金(81172697);国家自然科学基金(81302461);国家重大科学研究计划(2011CB933404);江苏省基础研究计划(BK2011606)~~

摘　　要：量子点作为一种新型的纳米材料,由于其独特的光电学特性可以广泛地应用于生物医学领域,因而其安全性已成为研究热点。中枢神经系统作为量子点作用的潜在靶器官之一,量子点的神经毒性研究也受到一些研究者的关注。量子点可跨越血脑屏障或通过神经通路进入中枢神经系统,产生破坏神经细胞结构和功能、损伤神经突触可塑性等神经毒性效应,其作用机制可能与氧化应激、炎症反应和离子通道改变3条途径有关。As quantum dots（ QDs）,an advanced porduct of nanotechnology,have been widely used in bio-medicine due to their unique photoelectric properties. QD safety evaluation has become a hot area of research. So far,some researchers have expressed concern about the neurotoxic potential of QDs because the central nervous system was confirmed to be one of the target organs. Several studies found that QDs could enter the central nervous system by crossing the blood brain barrier and following neural pathways and produce some neurotoxic effects,such as damaging the structure and function of neural cells and impairing synaptic plasticity. The potential toxicity mechanisms could include oxidative stress,inflammation and change of ion channels.

关 键 词：量子点 中枢神经系统 神经毒性效应 毒性机制 

分 类 号：R114[医药卫生—卫生毒理学]