壁冠状动脉血流动力学体外模拟  

In vitro simulation on hemodynamics of mural coronary artery

作　　者：丁皓[1,2] 杨琳[3] 兰海莲 尚昆[1,2] 张书宁[4] 孙爱军[4] 王克强[4] 沈力行[1,2] 葛均波[4] 

机构地区：[1]上海医疗器械高等专科学校医疗器械工程系,上海200093 [2]上海理工大学医疗器械与食品学院,上海200093 [3]复旦大学附属眼耳鼻喉科医院,实验中心上海200031 [4]复旦大学附属中山医院上海市心血管病研究所,上海200032

出　　处：《医用生物力学》2014年第5期432-439,共8页Journal of Medical Biomechanics

基　　金：国家重点基础研究发展(973)计划(2011CB503905);上海理工大学国家级项目培育基金项目(13XGM08);上海市教育委员会科研创新项目(13YZ148)

摘　　要：目的研究心肌桥压迫对壁冠状动脉内血流、正压力、周向应力、切应力的影响。方法对原有的壁冠状动脉模拟装置进行较大改进,使其测量的血流动力学参数从单一应力(正应力)扩展到多种应力,以便更全面准确地模拟在正压力、周向应力、切应力共同作用下的真实血流动力学环境,从而综合考虑在多种应力共同作用下血流动力学规律与壁冠状动脉粥样硬化之间的关联。结果壁冠状动脉模拟装置实验结果表明,应力的异常主要位于壁冠状动脉近端,随着心肌桥压迫程度加剧,近端的应力平均值与波动值明显增大,正应力平均值升高27.8%,波动值升高139%。结论心肌桥压迫造成壁冠状动脉近端血流动力学发生异常,对认识冠脉粥样硬化发病的血流动力学机理具有重要意义,对于心肌桥的病理影响及治疗具有潜在的临床价值。Objective To study the effect of myocardial bridge oppression on blood flow,positive pressure,circumferential stress and shear stress of the coronary artery.Methods The original myocardial bridge simulative device was greatly improved to be able to measure multi-hemodynamic parameters,such as normal stress,circumferential stress and shear stress,so as to exactly simulate real blood dynamics environment with the common effect of several stresses,and comprehensively investigate the relationship between hemodynamics and atherosclerosis of mural coronary artery under the combined effects of several stresses.Results The results from the myocardial bridge simulative device indicated that the hemodynamic abnormalities were mainly located in the proximal end of mural coronary artery,and the mean and oscillation values of normal stress at the proximal end were increased by 27.8％ and 139％,respectively,showing a significant increase with the intensification of myocardial bridge oppression.Conclusions It is myocardial oppression that causes the hemodynamic abnormity of proximal coronary artery,which is quite important for understanding the hemodynamic mechanism of coronary atherosclerotic diseases and valuable for studying pathological effects and treatments of the myocardial bridge in clinic.

关 键 词：心肌桥 壁冠状动脉 动脉粥样硬化 血流动力学 模拟装置 

分 类 号：R318.01[医药卫生—生物医学工程]